橄榄苦苷治疗妇科恶性肿瘤术后骨质疏松的机制研究进展

发布时间：2018-11-24 08:05

【摘要】：妇科恶性肿瘤发病率逐年上升,其中卵巢癌死亡率占5%,居妇科恶性肿瘤首位。治疗首选切除双侧卵巢,其术后骨质疏松发生率高,严重影响中老年女性生活质量。常用激素替代治疗(HRT)和植物雌激素(phyto-oestrogens,PE)治疗绝经后骨质疏松症,激素替代治疗虽然降低了骨质疏松和骨折的危险性,但增加了乳腺癌、子宫内膜癌等发病率。而大多数妇科恶性肿瘤是激素依赖型肿瘤,PE化学结构与17β-雌二醇相似,具有弱雌二醇作用,应用于妇科恶性肿瘤术后骨质疏松治疗安全性有待考证。橄榄苦苷是从天然橄榄油中提取的主要成分,不仅可以减少骨量丢失防治骨质疏松,还具有抗子宫内膜癌、抗乳腺癌等作用,已经成了较理想的治疗妇科恶性肿瘤术后骨质疏松的候选药。本文对近几年其治疗骨质疏松的可能机制做一综述。
[Abstract]:The incidence of gynecological malignant tumors increased year by year, of which ovarian cancer mortality accounted for 5, ranking first in gynecological malignant tumors. The first choice of treatment was bilateral ovariectomy, which had a high incidence of osteoporosis after operation, which seriously affected the quality of life of middle-aged and elderly women. Hormone replacement therapy (HRT) and phytoestrogen (phyto-oestrogens,PE) are commonly used to treat postmenopausal osteoporosis. Although hormone replacement therapy reduces the risk of osteoporosis and fracture, it increases the incidence of breast cancer and endometrial carcinoma. However, most gynecological malignant tumors are hormone dependent tumors. The chemical structure of PE is similar to 17 尾 -estradiol and has weak estradiol effect. Olive glycoside is the main component extracted from natural olive oil, which can not only reduce bone loss to prevent osteoporosis, but also has anti-endometrial cancer, anti-breast cancer and so on. It has become an ideal candidate for the treatment of postoperative osteoporosis of gynecologic malignant tumors. This article reviews the possible mechanism of osteoporosis treatment in recent years.
【作者单位】：厦门大学附属东方医院;
【基金】：南京军区医学科技创新课题(11M111)
【分类号】：R737.3;R580

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