子宫内膜异位症发病相关因素研究

发布时间：2018-11-25 13:08

【摘要】：目的：调查分析新疆部分地区子宫内膜异位症发病的一般流行病学特点,并探讨子宫内膜异位症发病的相关因素。方法：采用病例对照研究。病例组选取2011年12月至2013年9月于兰州军区乌鲁木齐总医院经手术病理证实为子宫内膜异位症的患者146例(包含1例伴阴道闭锁的青春期子宫内膜异位症)。对照组为同期门诊体检正常的妇女206例。首先对146例病例组患者资料进行单独分析；再除外病例组1例特殊病例资料后,对两组的月经初潮年龄、月经量、月经周期、经期、痛经、生育史、哺乳史、输卵管通液史或是输卵管造影史、吸烟史、避孕措施等方面进行单因素和多因素非条件Logistic回归模型分析,筛选出子宫内膜异位症发病相关因素。结果：经非条件单因素Logistic回归分析结果显示：月经初潮年龄、月经周期、输卵管通液或造影术、剖宫产次、避孕方法以及主动吸烟对子宫内膜异位症的发病无显著影响(P0.05),经量、经期、哺乳、孕次、不孕、人工流产或宫腔操作史与子宫内膜异位症的发病有显著相关性(P0.05)；控制混杂因素后,经多因素Logistic回归模型分析,结果显示：经期长(6天)、痛经、3次及以上人工流产术或宫腔操作史是子宫内膜异位症发病的危险因素(偏回顾系数β依次为2.007、1.779、2.050,OR值依次为7.981、5.921、7.769),P0.05,具有统计学意义；而经量少(20m1)、生产因素是子宫内膜异位症发病的保护因素(偏回归系数β依次为-1.322、-1.776、-2.387、-3.268,OR值依次为0.267、0.169、0.092、0.038),P0.05,具有统计学意义。结论：子宫内膜异位症发病的相关因素有经期长(6天)、经量少(20m1)、生产次数、痛经、3次及以上人工流产术或宫腔操作史；危险因素是经期6天、痛经、3次及以上人工流产或宫腔操作史：保护因素是经量20m1、生产次数多；因此缩短经期、缓解痛经、做好计划生育、减少人工流产术或宫腔操作次数有望减少或是预防子宫内膜异位症的发病。
[Abstract]:Objective: to investigate and analyze the general epidemiological characteristics of endometriosis in some areas of Xinjiang, and to explore the related factors of endometriosis. Methods: a case-control study was conducted. From December 2011 to September 2013, 146 patients with endometriosis (including 1 adolescent endometriosis with vaginal atresia) were selected from Urumqi General Hospital of Lanzhou military region. The control group was 206 women with normal physical examination in the same period. The data of 146 cases were analyzed separately. After one special case in the case group was excluded, the menarche age, menstrual volume, menstrual cycle, dysmenorrhea, birth history, lactation history, salpingography history, smoking history of the two groups were recorded. Univariate and multivariate non-conditional Logistic regression models were used to screen the related factors of endometriosis. Results: the unconditioned univariate Logistic regression analysis showed that: menarche age, menstrual cycle, fallopian tube effusion or contrast, cesarean section, Contraceptive methods and active smoking had no significant effect on the incidence of endometriosis (P0.05). The history of induced abortion or uterine cavity operation was significantly correlated with the incidence of endometriosis (P0.05). After controlling for confounding factors, multivariate Logistic regression model analysis showed that menstrual period was long (6 days), dysmenorrhea, dysmenorrhea, Three or more times of induced abortion or history of uterine cavity operation were the risk factors of endometriosis (partial retrospective coefficient 尾 was 2.007 / 1.779 / 2.050) (OR = 7.981 / 5.921 / 7.769), with statistical significance (P < 0.05). However, the factor of production was the protective factor of endometriosis (the partial regression coefficient 尾 was -1.322- 1.776- 2.387U -3.268m), and the OR was 0.267U 0.169U 0.092n 0.038, P 0.05, P < 0.05, P < 0.01). It has statistical significance. Conclusion: the related factors of endometriosis include long menstrual period (6 days), low menstrual volume (20m1), number of labor, dysmenorrhea, 3 or more induced abortion or history of uterine cavity operation. The risk factors were menstrual period 6 days dysmenorrhea 3 or more induced abortion or uterine cavity operation history. Therefore, shortening menstrual period, relieving dysmenorrhea, doing family planning well, reducing the number of induced abortion or uterine cavity operation are expected to reduce or prevent the incidence of endometriosis.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.71

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