宫颈癌患者周围神经侵犯的临床研究

发布时间：2018-11-26 09:33

【摘要】：目的:周围神经侵犯(perineural invasion,PNI)对宫颈癌病人预后的影响,目前没有一致的结论。本研究为探讨宫颈癌周围神经侵犯对预后的影响及其在维吾尔族和汉族间的差异。方法:回顾性分析2009-2014年413例(IB—IIB期)宫颈癌根治术后患者的临床病理资料。其中维吾尔族患者198例,汉族患者215例。研究宫颈癌神经侵犯与其它临床病理特征的关系及其对宫颈癌预后的意义。结果:宫颈癌神经侵犯的患者共有8.0%(33/413)例,其与淋巴结转移、肿块≥4cm、宫旁侵犯以及脉管癌栓均显著相关(P0.05)。PNI阳性组的5年无复发生存率为76.7%,明显低于阴性组84.6%,且差异显著(P=0.048)。PNI阳性组与阴性组的5年生存率分别为70.6%和79.9%,但无显著性差异(P=0.383)。针对不同民族患者进行亚组分析的结果显示:维吾尔族患者中PNI阳性亚组的5年无复发生存率明显低于PNI阴性亚组,且差异显著(P=0.034)。Cox多因素分析显示,神经侵犯不是影响宫颈癌术后患者生存的独立预后因素(P0.05)。结论:宫颈癌神经侵犯降低患者5年无复发生存率,且在维吾尔族患者中显著,但其不能作为判断宫颈癌预后的独立指标。因此,神经侵犯可能是宫颈癌的新候选危险因素。
[Abstract]:Objective: there is no consistent conclusion on the prognosis of cervical cancer patients with peripheral nerve invasion (perineural invasion,PNI). The purpose of this study was to investigate the influence of cervical cancer peripheral nerve invasion on prognosis and the difference between Uygur and Han nationalities. Methods: the clinicopathological data of 413 cases (IB-IIB stage) after radical resection of cervical cancer from 2009 to 2014 were analyzed retrospectively. There were 198 Uygur patients and 215 Han patients. To study the relationship between cervical carcinoma neuroinvolvement and other clinicopathological features and its prognostic significance. Results: there were 8. 0% (33 / 413) cases of cervical carcinoma with nerve invasion, which were associated with lymph node metastasis, mass 鈮，

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