PIK3CA、TIEG1在老年卵巢癌组织中的表达及意义

发布时间：2018-11-28 07:47

【摘要】：目的比较老年卵巢癌、癌旁组织和正常卵巢组织的磷脂酰肌醇3磷激酶催化亚基α基因(PIK3CA)、转化生长因子(TGF)-1诱导的早期反应基因(TIEG1)表达差异及其与卵巢癌病理特征间的相关性。方法手术治疗的40例老年宫颈癌患者手术过程中均取适量卵巢癌组织、癌旁组织和正常卵巢组织,行石蜡切片。比较三种组织的PIK3CA、TIEG1表达差异及其与卵巢癌病理特征间的相关性。结果三种组织的PIK3CA阳性表达有显著性差异(χ2=50.76,P0.01),卵巢癌阳性表达最高,正常卵巢组织最低;三种组织的TIEG1阳性表达有显著性差异(χ2=26.27,P0.01),其中卵巢癌最低,正常卵巢最高。卵巢癌组织的PIK3CA阳性表达与组织学分级(χ2=10.72,P=0.005)、淋巴结转移(χ2=4.191,P=0.041)均有显著的相关性;TIEG1阳性表达率与组织学分级(χ2=9.462,P=0.009)、淋巴结转移(χ2=9.724,P=0.002)也有显著的相关性。结论PIK3CA、TIEG1在卵巢癌中的表达与正常卵巢组织有显著性差异,两者与卵巢癌的发展、转移有一定相关性。
[Abstract]:Objective to compare the phosphatidylinositol 3 phosphokinase catalytic subunit 伪 (PIK3CA) gene in ovarian cancer, paracancerous tissues and normal ovarian tissues. Expression of early response Gene (TIEG1) induced by Transforming growth Factor (TGF)-1 and its correlation with pathological characteristics of Ovarian Cancer. Methods 40 elderly patients with cervical cancer were treated with paraffin sections, including ovarian cancer tissue, paracancerous tissue and normal ovarian tissue. To compare the difference of PIK3CA,TIEG1 expression in the three tissues and its correlation with the pathological features of ovarian cancer. Results the positive expression of PIK3CA was significantly different among the three tissues (蠂 2 + 50.76 卤P0.01). The positive expression of PIK3CA was the highest in ovarian cancer and the lowest in normal ovarian tissue. The positive expression of TIEG1 was significantly different among the three tissues (蠂 2 + 26.27% P0.01), the ovarian cancer was the lowest and the normal ovary was the highest. The positive expression of PIK3CA in ovarian carcinoma was significantly correlated with histological grade (蠂 2 + 10. 72% P0. 005) and lymph node metastasis (蠂 2 + 4. 191% P + 0. 041). The positive expression rate of TIEG1 was also significantly correlated with histological grade (蠂 29.462) and lymph node metastasis (蠂 2 + 9.724% P0. 002). Conclusion the expression of PIK3CA,TIEG1 in ovarian cancer is significantly different from that in normal ovarian tissue, and there is a certain correlation between the expression of PIK3CA,TIEG1 and the development and metastasis of ovarian cancer.
【作者单位】：内蒙古医科大学附属医院妇产科;
【基金】：内蒙古卫生厅2010年医疗卫生科研计划项目任务书项目(No.2010124)
【分类号】：R737.31

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