胰岛素抵抗对多囊卵巢综合征患者血清性激素水平的影响

发布时间：2018-12-07 19:38

【摘要】：目的探讨胰岛素抵抗(IR)对多囊卵巢综合征(PCOS)患者血清性激素水平的影响及机制。方法研究对象为同期收治的64例POCS患者(POCS组),其中伴IR(IR指数1.95)48例、不伴IR 18例;同期40例正常育龄期健康体检者为正常组。采用免疫发光法检测两组血清性激素[雌二醇(E2)、睾酮(T)、脱氢表雄酮(DHEA)]水平;分析POCS组性激素水平与IR指数的相关性。结果 PCOS组血清E2、T、DHEA水平均高于对照组(P均0.05);POCS伴IR者血清T、DHEA水平高于不伴IR者(P均0.05);PCOS患者血清T、DHEA水平与IR间呈显著正相关(r=0.574、0.428,P均0.05),而血清E2水平与IR无相关性。结论血清性激素水平可作为新的检测指标提高PCOS伴IR的诊断水平。
[Abstract]:Objective to investigate the effect and mechanism of insulin resistance (IR) on serum sex hormone levels in patients with polycystic ovary syndrome (PCOS). Methods Sixty-four patients with POCS (POCS group) were treated in the same period, including 48 patients with IR (IR index (1.95), 18 patients without IR, and 40 healthy persons with normal reproductive age. The serum levels of estradiol (E2) and testosterone (T), dehydroepiandrosterone (DHEA) were measured by immunoluminescent method, and the correlation between sex hormone level and IR index in POCS group was analyzed. Results the serum levels of PCOS in patients with PCOS were significantly higher than those in the controls (P 0.05). The levels of serum THEA in patients with IR were significantly higher than those in patients without IR (P 0.05). There was a significant positive correlation between serum Tet DHEA and IR in PCOS patients (r = 0.574, 0.428, P 0.05), but no correlation was found between serum E _ 2 and IR. Conclusion Serum sex hormone level can be used as a new index to improve the diagnostic level of PCOS with IR.
【作者单位】：汕头大学医学院第一附属医院;
【基金】：广东省汕头市医疗科技计划项目(汕府科[2012]113号)
【分类号】：R711.75

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