补肾法联合HCG治疗黄体功能不全性不孕症的临床研究
发布时间：2018-12-08 11:54
【摘要】：目的：本研究旨在观察补肾法联合HCG治疗肾虚型黄体功能不全性不孕症的临床疗效，，探讨其中西医结合治疗的作用机制。 方法：将60例中医辨证为肾虚型、西医诊断为黄体功能不全所致的不孕症患者随机分为治疗组和对照组各30例，治疗组采用补肾养精汤联合HCG治疗，对照组采用六味地黄软胶囊、还少胶囊及HCG治疗，3个月为一个疗程，观察患者的临床疗效及用药前后的临床症状、基础体温、内分泌激素水平以及B超监测卵泡、子宫内膜等变化。 结果：补肾法联合HCG治疗肾虚型黄体功能不全所致的不孕症的临床妊娠率为77%，在整体证候改善方面，总有效率为93%，均明显高于对照组（P0.05）。患者基础体温以及高温相评分均有明显的改善（P0.05）。治疗组在黄体中期血清孕酮水平明显高于对照组，两组间差异有显著性（P0.05）。在改善子宫内膜厚度方面，治疗后子宫内膜厚度明显增厚（P0.05）。在影响卵泡发育方面，治疗后卵泡直径明显增大（P0.05）。 结论：补肾中药治疗肾虚型黄体功能不全性不孕症，可以通过调节自身的下丘脑-垂体-卵巢轴的功能，来促进卵泡成熟发育、卵巢黄体的生成，改善内分泌条件，增加子宫内膜的厚度，明显缩短基础体温的移行时间，增加高温相持续时间及其稳定性等。补肾法联合HCG治疗黄体功能不全性不孕症有很好的临床疗效，明显提高临床妊娠率，对内分泌有很好的调节作用。
[Abstract]:Objective: to observe the clinical effect of tonifying kidney method combined with HCG in the treatment of luteal insufficiency infertility of kidney deficiency type, and to explore the mechanism of combination of traditional Chinese and western medicine. Methods: sixty cases of infertility caused by luteal insufficiency were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with Bushen Yangjing decoction combined with HCG. The control group was treated with Liuwei Dihuang soft capsule, Xiaoxiao capsule and HCG for a course of three months. The clinical effect and clinical symptoms, basic body temperature, endocrine hormone level and B-ultrasound monitoring of follicles were observed. Changes in the endometrium. Results: the clinical pregnancy rate of kidney tonifying method combined with HCG in treating infertility caused by luteal insufficiency of kidney deficiency type was 77. The total effective rate of improving the overall syndromes was 93, which was significantly higher than that of the control group (P0.05). Patients with basic body temperature and hyperthermia score were significantly improved (P0.05). The serum progesterone level in the middle luteal phase in the treatment group was significantly higher than that in the control group, and the difference between the two groups was significant (P0.05). In terms of improving endometrial thickness, endometrial thickness was significantly thickened after treatment (P0.05). The follicle diameter increased significantly after treatment (P0.05). Conclusion: Chinese medicine for tonifying the kidney can promote follicular maturation, luteal formation and endocrine condition by regulating the function of hypothalamus-pituitary-ovarian axis in the treatment of renal deficiency type luteal insufficiency infertility. Increasing the thickness of endometrium, shortening the migration time of basic body temperature, increasing the duration of hyperthermia and its stability, etc. Kidney tonifying method combined with HCG in the treatment of luteal insufficiency infertility has a good clinical efficacy, significantly improve the clinical pregnancy rate, and has a good endocrine regulation.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.6
[Abstract]:Objective: to observe the clinical effect of tonifying kidney method combined with HCG in the treatment of luteal insufficiency infertility of kidney deficiency type, and to explore the mechanism of combination of traditional Chinese and western medicine. Methods: sixty cases of infertility caused by luteal insufficiency were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with Bushen Yangjing decoction combined with HCG. The control group was treated with Liuwei Dihuang soft capsule, Xiaoxiao capsule and HCG for a course of three months. The clinical effect and clinical symptoms, basic body temperature, endocrine hormone level and B-ultrasound monitoring of follicles were observed. Changes in the endometrium. Results: the clinical pregnancy rate of kidney tonifying method combined with HCG in treating infertility caused by luteal insufficiency of kidney deficiency type was 77. The total effective rate of improving the overall syndromes was 93, which was significantly higher than that of the control group (P0.05). Patients with basic body temperature and hyperthermia score were significantly improved (P0.05). The serum progesterone level in the middle luteal phase in the treatment group was significantly higher than that in the control group, and the difference between the two groups was significant (P0.05). In terms of improving endometrial thickness, endometrial thickness was significantly thickened after treatment (P0.05). The follicle diameter increased significantly after treatment (P0.05). Conclusion: Chinese medicine for tonifying the kidney can promote follicular maturation, luteal formation and endocrine condition by regulating the function of hypothalamus-pituitary-ovarian axis in the treatment of renal deficiency type luteal insufficiency infertility. Increasing the thickness of endometrium, shortening the migration time of basic body temperature, increasing the duration of hyperthermia and its stability, etc. Kidney tonifying method combined with HCG in the treatment of luteal insufficiency infertility has a good clinical efficacy, significantly improve the clinical pregnancy rate, and has a good endocrine regulation.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.6
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