1945例稽留流产的流行病学及高危因素分析

发布时间：2018-12-08 20:02

【摘要】：目的:探讨稽留流产发生的高危因素。方法:通过病例-对照回顾性研究,收集稽留流产病例1 945例,同时与1 874例因非意愿妊娠20周内的单活胎要求终止妊娠者(包括妊娠12周自愿要求终止妊娠者以及妊娠12~20周内因内外科因素不宜妊娠者)的病例资料进行对比。分析与稽留流产发病相关的高危因素及环境等因素在稽留流产中可能产生的影响。结果:1Logistic多因素回归分析显示,与1 945例稽留流产发病正相关的危险因素包括:室外职业者(OR=1.777,95%CI=1.538~2.052),初产妇(OR=2.305,95%CI=2.013~2.638),自然流产史(OR=2.359,95%CI=1.703~3.268),贫血(OR=5.498,95%CI=2.243~13.473),乙肝病毒携带者(OR=8.126,95%CI=4.688~14.084);与稽留流产发病负相关的危险因素为人工流产≥3次(OR=0.726,95%CI=0.573~0.920)。2稽留流产独立因素构成变化显示,环境因素及一些未知因素等构成比升高(P0.05),与稽留流产发病数增加有关。结论:室外职业者、初产妇、自然流产病史、贫血和乙肝病毒携带者是稽留流产发生的独立危险因素,其中环境因素及一些未知因素的构成比随稽留流产发病数增加而升高。初步推论:基因、生育史、合并症不能解释稽留流产发病数的升高,而环境因素和一些未知因素可能是稽留流产病例数升高的重要原因之一。
[Abstract]:Objective: to explore the high risk factors of missed abortion. Methods: a retrospective case-control study was conducted to collect 1 945 cases of missed abortion. At the same time, the data of 1 874 cases of single live pregnancy requesting termination of pregnancy within 20 weeks of unwanted pregnancy (including those who voluntarily requested termination of pregnancy at 12 weeks of pregnancy and those who were not suitable for pregnancy due to internal and surgical factors within 20 weeks of gestation) were compared. To analyze the influence of high risk factors and environmental factors related to the incidence of missed abortion in missed abortion. Results: 1Logistic multivariate regression analysis showed that the risk factors associated with 1 945 cases of missed abortion were: outdoor occupational group (OR=1.777,95%CI=1.538~2.052), primipara (OR=2.305,95%CI=2.013~2.638), and the risk factors were: outdoor occupation (OR=1.777,95%CI=1.538~2.052), primipara (OR=2.305,95%CI=2.013~2.638). History of spontaneous abortion (OR=2.359,95%CI=1.703~3.268), anemia (OR=5.498,95%CI=2.243~13.473), hepatitis B virus carriers (OR=8.126,95%CI=4.688~14.084); The risk factors negatively correlated with the incidence of missed abortion were induced abortion 鈮，

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