左炔诺孕酮宫内缓释系统预防子宫内膜息肉复发的疗效分析

发布时间：2018-12-12 20:56

【摘要】：目的探讨宫腔镜下子宫内膜息肉电切术后应用左炔诺孕酮宫内缓释系统(LNG-IUS)预防子宫内膜息肉复发的疗效。方法将2009年8月-2011年8月郑州大学第一附属医院因子宫内膜息肉行宫腔镜下子宫内膜息肉电切术的60例患者,采用完全随机化分组法分为研究组(30例,术后放置LNG-IUS)和对照组(30例,术后未行特殊处理)。随访比较两组患者术后6、12、24个月子宫内膜息肉复发、血红蛋白水平和子宫内膜厚度。结果研究组患者治疗后24个月血红蛋白水平[(120.15±9.51)]g/L显著增加(P0.05);术后6、12、24个月子宫内膜厚度[(0.57±0.14)mm、(0.79±0.21)mm、(0.93±0.22)mm]均低于治疗前[(1.46±0.56)mm](P0.05);术后24个月子宫内膜息肉的复发率(6.90%,2/29)与对照组(39.29%,11/28)比较,差异有统计学意义(P0.05)。所有患者术后均无严重并发症发生,术后24个月随访,研究组2例(6.90%,2/29)患者有阴道淋漓出血。结论左炔诺孕酮宫内缓释系统能有效预防子宫内膜息肉复发,值得在临床推广。
[Abstract]:Objective to evaluate the efficacy of levonorgestrel (LNG-IUS) in preventing the recurrence of endometrial polyps after hysteroscopic resection of endometrial polyps. Methods from August 2009 to August 2011, 60 patients with endometrial polyps treated by hysteroscopy in the first affiliated Hospital of Zhengzhou University were randomly divided into study group (n = 30) and control group (n = 30). LNG-IUS was placed after operation and control group (30 cases, without special treatment). The recurrence of endometrial polyps, hemoglobin level and endometrial thickness were compared between the two groups at 612 and 24 months postoperatively. Results the hemoglobin level in the study group was significantly increased 24 months after treatment [(120.15 卤9.51)] g / L (P0.05). Endometrial thickness [(0.57 卤0.14) mm, () 0.79 卤0.21) mm, (0.93 卤0.22 mm] was lower than that before treatment [(1.46 卤0.56) mm] (P0.05). 24 months after operation, the recurrence rate of endometrial polyps (6.90 / 29) was significantly higher than that of control group (39.29%) (P 0.05). There were no serious complications in all patients. 2 patients in study group (6.90 to 2 / 29) had vaginal bleeding after 24 months follow-up. Conclusion levonorgestrel intrauterine sustained release system can effectively prevent the recurrence of endometrial polyps and is worth popularizing in clinic.
【作者单位】：郑州市妇幼保健院;郑州大学第一附属医院;
【分类号】：R713.4

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