新鲜胚胎与冻融胚胎移植后引起宫内外同时妊娠69例临床分析

发布时间：2018-12-17 15:44

【摘要】：目的探讨辅助生殖技术(ART)引起宫内外同时妊娠(HP)的影响因素。方法采用单因素及多因素Logistic回归分析的方法对经辅助生殖助孕治疗后发生HP的69例(新鲜胚胎移植35例,冻融胚胎移植34例)患者的临床资料进行回顾性分析。结果同期新鲜周期组临床妊娠6 616例,其中HP患者35例(0.53%);冻融周期组临床妊娠3 516例,其中HP患者34例(0.97%),冻融周期组中HP发生率与新鲜胚胎周期组比较,差异有统计学意义(P=0.01);HP组与宫内双胎妊娠对照组和单纯异位妊娠对照组年龄、不孕年限、获卵数、G n用量、h C G注射日的血清E2值、孕酮值、内膜厚度、移植管距宫底距离、不孕类型之间比较,差异均无统计学意义(P0.05)。HP组中有宫腔操作史46.37%(32/69),高于宫内双胎妊娠的26.25%(42/160),差异有统计学意义(P0.05);HP组中输卵管妊娠史有39.13%(27/69),高于宫内双胎妊娠的23.12%(37/160),差异有统计学意义(P0.05)。结论 ART中获卵数、Gn用量、h CG注射日的血清E2值、孕酮值、内膜厚度、移植管距宫底距离、不孕类型对HP的发生影响不大,既往有输卵管妊娠史、宫腔操作史及冻融周期中人工周期治疗方案与H P的发生有明显的相关性。
[Abstract]:Objective to investigate the influencing factors of (HP) induced by assisted reproductive technology (ART) during intrauterine and extrauterine pregnancy. Methods the clinical data of 69 patients with HP (35 fresh embryo transfer and 34 frozen thawed embryo transfer) after assisted reproductive assisted pregnancy therapy were analyzed retrospectively by univariate and multivariate Logistic regression analysis. Results in the same period fresh cycle group, there were 6 616 cases of clinical pregnancy, of which 35 cases (0.53%) were HP. There were 3 516 cases of clinical pregnancy in freeze-thaw cycle group, 34 cases (0.97%) with HP. The incidence of HP in freeze-thaw cycle group was significantly higher than that in fresh embryo cycle group (P0.01). HP group, intrauterine twin pregnancy control group and simple ectopic pregnancy control group, age, infertile years, number of eggs, G n dosage, h C G injection day serum E2 value, progesterone value, intimal thickness, the distance from the transplanted tube to the fundus of uterus. There was no significant difference between the types of infertility (P0.05). HP group had uterine cavity operation history 46.37% (32 / 69), higher than the intrauterine twin pregnancy 26.25% (42 / 160), the difference was statistically significant (P0.05); The history of tubal pregnancy in HP group was 39.13% (27 / 69), higher than that in intrauterine twin pregnancy (23.12%) (37 / 160), the difference was statistically significant (P0.05). Conclusion the number of eggs obtained in ART, the serum E2 value, progesterone value, intimal thickness, the distance between the transplanted tube and the uterine floor, the type of infertility had little influence on the occurrence of HP, and the history of tubal pregnancy was not significant. The history of uterine cavity operation and artificial cycle therapy in freeze-thaw cycle were significantly correlated with the occurrence of HP.
【作者单位】：广西壮族自治区卫生和计划生育委员会生殖中心;
【分类号】：R714.8

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