阴道B群链球菌感染对产妇胎膜早破的影响研究

发布时间：2018-12-25 14:56

【摘要】：目的探讨阴道B群链球菌感染对胎膜早破的影响,为临床防治提供依据。方法回顾性分析2016年1-10月于医院产科分娩的4 285例孕妇的临床资料,选择其中396例胎膜早破孕妇作为观察组,剩余3 889例无胎膜早破的孕妇为对照组;分析阴道B群链球菌感染率及药物敏感性,阴道B群链球菌感染孕妇产后体温、产褥感染情况,阴道B群链球菌感染对胎膜早破及新生儿合并症的影响。结果 4 285例孕妇共检出阴道B群链球菌感染者453例,检出率为10.6%;B群链球菌耐药性分析结果显示,对青霉素、氨苄西林、利奈唑胺、头孢唑林、万古霉素、头孢曲松的敏感率达100.0%,对氯霉素、四环素、红霉素耐药率较高,分别为100.0%、98.9%、92.9%;阴道B群链球菌阳性孕妇产后会阴感染与宫内感染率显著高于阴道B群链球菌阴性孕妇(P0.01);观察组阴道B群链球菌阳性率为19.7%显著高于对照组的5.0%(P0.01);阴道B群链球菌阳性孕妇早产、新生儿肺炎、宫内窘迫的发生率显著高于对照组(P0.01)。结论阴道B群链球菌感染孕妇会增加产褥感染、胎膜早破、新生儿肺炎、宫内窘迫的风险,因而一旦发现阴道B群链球菌感染应积极应用抗菌药物进行治疗。
[Abstract]:Objective to investigate the effect of Streptococcus vaginalis B infection on premature rupture of fetal membrane. Methods the clinical data of 4 285 pregnant women who gave birth in hospital from January to October 2016 were analyzed retrospectively. 396 pregnant women with premature rupture of membranes were selected as observation group and the remaining 3 889 pregnant women without premature rupture of membranes as control group. To analyze the infection rate and drug sensitivity of group B streptococcus vaginalis, the postpartum temperature and puerperal infection of pregnant women with group B vaginal infection, and the influence of group B Streptococcus vaginalis infection on premature rupture of membranes and neonatal complications. Results 453 cases of Streptococcus vaginalis were detected in 4 285 pregnant women, the positive rate was 10.6%. The results of drug resistance analysis of group B streptococcus showed that the sensitivity to penicillin, ampicillin, linazolamine, cefazolin, vancomycin and ceftriaxone was 100.0.The resistance rate to chloramphenicol, tetracycline and erythromycin was higher. 100.0 and 98.9, respectively. The postpartum perineum infection and intrauterine infection rate of Group B Streptococcus vaginalis positive pregnant women were significantly higher than those of Group B Streptococcus vaginalis negative pregnant women (P0.01). The positive rate of streptococcus vaginalis in group B was significantly higher than that in group B (5.0%, P0.01), and the incidence of premature delivery, neonatal pneumonia and intrauterine distress in group B was significantly higher than that in control group (P0.01). Conclusion the risk of puerperal infection, premature rupture of fetal membrane, neonatal pneumonia and intrauterine distress can be increased in pregnant women with group B streptococcus vaginalis infection. Therefore, antimicrobial agents should be used to treat group B Streptococcus vaginalis infection once found.
【作者单位】：绍兴市中心医院妇产科;
【基金】：浙江省卫生厅医药科技计划基金资助项目(20152339)
【分类号】：R714.433

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