同步放化疗与单纯放疗辅助治疗术后高危子宫内膜癌的临床疗效比较

发布时间：2019-01-04 18:05

【摘要】：目的对比研究顺铂(DDP)联合5-氟尿嘧啶(5-FU)同步放化疗与单纯放疗辅助治疗术后高危子宫内膜癌的毒性反应和复发率。方法有高危因素的子宫内膜癌患者43例中22例行单纯放射治疗,21例行术后辅助DDP+5-FU(PF)方案同步放化疗治疗,对比两组毒性反应和复发率。结果同步放化疗组与单纯放疗组3级胃肠道反应率分别为61.90%和31.82%,差异显著(P0.05);2级以上骨髓抑制率分别为66.67%和18.18%,差异显著(P0.01);2级以上周围神经毒性反应率分别为33.33%和13.64%,无显著差异(P0.05),总体复发率分别为4.76%和27.27%,差异显著(P0.05)。结论高危子宫内膜癌患者同步放化疗后3级胃肠道反应率增加,2级以上骨髓抑制率显著增加,周围神经毒性反应率不增加,毒性反应可以耐受,减少2年总体复发率。
[Abstract]:Objective to compare the toxicity and recurrence rate of cisplatin (DDP) combined with 5 fluorouracil (5-FU) combined with radiotherapy alone in the treatment of high risk endometrial carcinoma. Methods in 43 cases of endometrial carcinoma with high risk factors, 22 cases were treated with radiotherapy alone and 21 cases were treated with concurrent radiotherapy and chemotherapy with DDP 5-FU (PF) regimen after operation. The toxic reaction and recurrence rate were compared between the two groups. Results the rate of gastrointestinal reaction in concurrent radiotherapy group and radiotherapy group was 61.90% and 31.82%, respectively (P0.05), the rate of bone marrow suppression above grade 2 was 66.67% and 18.18%, respectively (P0.01). The rate of peripheral neurotoxic reaction above grade 2 was 33.33% and 13.64 respectively, there was no significant difference (P0.05), the overall recurrence rate was 4.76% and 27.27%, the difference was significant (P0.05). Conclusion after concurrent radiotherapy and chemotherapy, the rate of gastrointestinal tract reaction in patients with high risk endometrial carcinoma was increased, the rate of bone marrow suppression above grade 2 was significantly increased, but the rate of toxic reaction of peripheral nerve was not increased. The toxic reaction was tolerable and the overall recurrence rate of 2 years was decreased.
【作者单位】：昆明医科大学第三附属医院(云南省肿瘤医院)妇瘤科;
【基金】：云南省卫生科技计划项目(No.2012WS0042)
【分类号】：R737.33

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