血清γ干扰素诱导蛋白16水平与子痫前期发病的相关性研究
发布时间：2019-01-06 12:45
【摘要】：目的探讨人γ干扰素诱导蛋白16(IFI16)在子痫前期患者血清中的水平及其与子痫前期发病的相关性。方法选取2015年8月到2016年3月在郑州大学第三附属医院就诊的子痫前期孕妇45例为子痫前期组,同期进行常规孕期检查的30例健康孕妇为对照组。采用全自动生化分析仪检测血清中尿素氮、尿酸、肌酐等生化指标;采用ELISA方法检测血清中IFI16和内皮素-1(ET-1)的水平,并对血清IFI16水平与各检测指标之间的相关性进行分析;受试者工作特征(ROC)曲线用于评判血清IFI16水平在预测子痫前期疾病中的价值。结果 IFI16和ET-1在子痫前期组孕妇血清中的水平明显高于对照组(P0.01);重度子痫前期孕妇血清IFI16水平高于轻度子痫前期孕妇(P0.01)。子痫前期孕妇血清中IFI16水平与收缩压、舒张压、24h尿蛋白定量和血清ET-1水平呈明显正相关,与血清清蛋白水平呈负相关。以血清IFI16水平为14.47ng/mL和17.09ng/mL作为预测子痫前期及鉴别轻度子痫前期和重度子痫前期的临界值时具有较高的灵敏度和特异性。结论孕妇血清中高水平的IFI16与子痫前期的发病具有一定相关性,并有可能成为预测子痫前期发生的新的生物学指标。
[Abstract]:Objective to investigate the level of human interferon-纬 inducible protein 16 (IFI16) in serum of preeclampsia patients and its correlation with preeclampsia. Methods from August 2015 to March 2016, 45 preeclampsia pregnant women in the third affiliated Hospital of Zhengzhou University were selected as preeclampsia group and 30 normal pregnant women as control group. Serum urea nitrogen, uric acid and creatinine were detected by automatic biochemical analyzer. The levels of IFI16 and ET-1 in serum were detected by ELISA method, and the correlation between serum IFI16 level and each index was analyzed. The operating characteristic (ROC) curve was used to evaluate the value of serum IFI16 level in predicting preeclampsia. Results the serum levels of IFI16 and ET-1 in the preeclampsia group were significantly higher than those in the control group (P0.01), and the serum IFI16 levels in the severe preeclampsia group were higher than those in the mild preeclampsia group (P0.01). The serum levels of IFI16 in preeclampsia were positively correlated with systolic blood pressure, diastolic blood pressure, 24-hour urinary protein and serum ET-1 levels, and negatively correlated with serum albumin levels. Using serum IFI16 levels as 14.47ng/mL and 17.09ng/mL as critical values for predicting preeclampsia and differentiating mild and severe preeclampsia has high sensitivity and specificity. Conclusion the high level of IFI16 in maternal serum may be a new biological index to predict the occurrence of preeclampsia.
【作者单位】： 郑州大学第三附属医院检验科;商丘医学高等专科学校;
【分类号】：R714.244
[Abstract]:Objective to investigate the level of human interferon-纬 inducible protein 16 (IFI16) in serum of preeclampsia patients and its correlation with preeclampsia. Methods from August 2015 to March 2016, 45 preeclampsia pregnant women in the third affiliated Hospital of Zhengzhou University were selected as preeclampsia group and 30 normal pregnant women as control group. Serum urea nitrogen, uric acid and creatinine were detected by automatic biochemical analyzer. The levels of IFI16 and ET-1 in serum were detected by ELISA method, and the correlation between serum IFI16 level and each index was analyzed. The operating characteristic (ROC) curve was used to evaluate the value of serum IFI16 level in predicting preeclampsia. Results the serum levels of IFI16 and ET-1 in the preeclampsia group were significantly higher than those in the control group (P0.01), and the serum IFI16 levels in the severe preeclampsia group were higher than those in the mild preeclampsia group (P0.01). The serum levels of IFI16 in preeclampsia were positively correlated with systolic blood pressure, diastolic blood pressure, 24-hour urinary protein and serum ET-1 levels, and negatively correlated with serum albumin levels. Using serum IFI16 levels as 14.47ng/mL and 17.09ng/mL as critical values for predicting preeclampsia and differentiating mild and severe preeclampsia has high sensitivity and specificity. Conclusion the high level of IFI16 in maternal serum may be a new biological index to predict the occurrence of preeclampsia.
【作者单位】： 郑州大学第三附属医院检验科;商丘医学高等专科学校;
【分类号】：R714.244
【相似文献】
相关期刊论文 前10条
1 孟涛;李辉;刘彤;潘莉莉;;脂联素及氧化修饰低密度脂蛋白在子痫前期中的测定及意义[J];中国优生与遗传杂志;2006年06期
2 桑翠琴;张震宇;王淑珍;刘浩;郭淑丽;;重度子痫前期/子痫合并急性呼吸窘迫综合征的诊断与处理[J];中国医刊;2006年10期
3 赵桂花;;重度子痫前期与子痫82例临床分析[J];临床医药实践杂志;2007年01期
4 杨小颀;严妮子;;子痫前期与血钙水平相关性研究[J];实用临床医学;2007年04期
5 杨小颀;严妮子;;子痫前期与血钙水平相关性研究[J];四川生理科学杂志;2007年01期
6 陈茜;王泽华;;子痫前期的预测及预防[J];华中医学杂志;2007年03期
7 朱倩;;对38例子痫前期(重)、子痫治愈的体会[J];实用预防医学;2007年05期
8 梁英;周丽丽;甘娟;姜碧洋;杨承东;;重度子痫前期在产科ICU监护救治的临床分析[J];中国妇幼保健;2008年19期
9 詹卫星;郑九生;;血管紧张素转换酶基因多态性与重度子痫前期及肾功能损害的关系[J];江西医药;2008年08期
10 蔡颖;尹国武;姜锋;李怡;闵保华;王s，
本文编号：2402801
本文链接：https://www.wllwen.com/yixuelunwen/fuchankeerkelunwen/2402801.html
最近更新
教材专著
