孕期个体化补充叶酸对母婴结局的影响

发布时间：2019-01-09 12:46

【摘要】：目的观察孕期个体化补充叶酸对母婴结局的影响。方法对5 621例孕妇(观察组)孕前及孕早期根据其叶酸代谢通路中关键酶基因的等位基因频率进行风险分层后实施个体化补服叶酸,3 000例孕妇(对照组)虽接受健康指导但孕前和孕期并无统一、规范并严格执行的叶酸补充方案。妊娠结束前检测孕妇血浆同型半胱氨酸(HCY)及血清叶酸,并随访其妊娠并发症和胎儿不良结局情况。结果观察组血清叶酸(8.09±1.39)μg/L、血浆HCY(7.63±2.50)μmol/L,对照组分别为(6.33±1.21)、(10.34±1.51)μg/L,P均0.01。观察组妊娠期高血压疾病、早产及低出生体质量儿、早产儿、胎儿心脏结构异常、开放性神经管畸形发生率均低于对照组,P均0.05。结论个体化补充叶酸可减少妊娠并发症和胎儿不良结局的发生。
[Abstract]:Objective to observe the effect of folic acid supplementation on maternal and infant outcomes during pregnancy. Methods 5 621 pregnant women (observation group) were divided into two groups according to the allele frequency of key enzyme gene in folic acid metabolism pathway before and at the beginning of pregnancy. 3 000 pregnant women (control group) received health guidance but there was no uniform folic acid supplementation program before and during pregnancy. Plasma homocysteine (HCY) and serum folic acid were measured before pregnancy, and pregnancy complications and fetal adverse outcomes were followed up. Results Serum folic acid (8.09 卤1.39) 渭 g / L and plasma HCY (7.63 卤2.50) 渭 mol/L, control group were (6.33 卤1.21), (10.34 卤1.51) 渭 g / L, respectively. The incidence of hypertensive disorder complicating pregnancy, premature and low birth weight infants, premature infants, abnormal fetal heart structure and open neural tube malformation in the observation group were lower than those in the control group (P < 0.05). Conclusion individualized folic acid supplementation can reduce the incidence of pregnancy complications and fetal adverse outcome.
【作者单位】：烟台市烟台山医院;
【基金】：中国疾病预防控制中心妇幼保健中心妇幼保健分子遗传医学研究专项计划项目(FY-ZX-ZD-0059)
【分类号】：R715.3

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