叶酸受体α在子宫内膜癌患者血清中的表达及临床意义

发布时间：2019-01-11 07:26

【摘要】：目的:探讨子宫内膜癌患者血清中叶酸受体α(FRA)的表达情况及其临床应用意义。方法:收集37例子宫内膜癌、33例子宫内膜增生症及10例正常内膜组织患者的血清标本,采用ELISA法对其表达情况进行检测。分析各组血清FRA的表达情况和差异,以及血清FRA的表达水平与子宫内膜癌临床病理特征的关系。结果:在正常人及子宫内膜病变患者血清中均可检测到FRA的表达。血清FRA在正常组、子宫内膜增生症组、子宫内膜癌组的表达水平逐步升高,且差异具有统计学意义(P0.05)。子宫内膜癌组中,血清FRA的表达水平在FIGO分期、肌层浸润深度方面的比较,差异有统计学意义(P0.05)。而在不同年龄、绝经与否、肿瘤的分化程度等方面比较,差异无统计学意义(P0.05)。结论:血清中能检测到FRA的表达,其表达水平可能有助于子宫内膜癌的诊断、治疗及预后情况的判断。
[Abstract]:Objective: to investigate the expression of folate receptor 伪 (FRA) in serum of patients with endometrial carcinoma and its clinical significance. Methods: the serum samples of 37 cases of endometrial carcinoma, 33 cases of endometrial hyperplasia and 10 cases of normal endometrial tissue were collected and detected by ELISA method. The expression of serum FRA and the relationship between the expression of serum FRA and the clinicopathological features of endometrial carcinoma were analyzed. Results: the expression of FRA was detected in the serum of normal subjects and patients with endometrial lesions. The expression of serum FRA in normal group, endometrial hyperplasia group, endometrial carcinoma group increased gradually, and the difference was statistically significant (P0.05). In endometrial carcinoma group, the expression of serum FRA in FIGO stage, depth of myometrium infiltration, the difference was statistically significant (P0.05). However, there was no significant difference in age, menopause or not, tumor differentiation and other aspects (P0.05). Conclusion: the expression of FRA can be detected in serum, which may be helpful to the diagnosis, treatment and prognosis of endometrial carcinoma.
【作者单位】：南方医科大学附属小榄医院妇产科;南方医科大学;
【基金】：广东省科技计划项目(编号:2013B021800113) 中山市科技计划项目(编号:2014A1FC020)
【分类号】：R737.33

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