子痫前期患者血浆网膜素及瘦素水平研究

发布时间：2019-01-16 09:10

【摘要】：目的检测正常妊娠和子痫前期(preeclampsia)患者血浆网膜素(Omentin)及瘦素(Leptin)的水平变化,探究其与子痫前期的发病关系及意义,从而探讨网膜素及瘦素是否对子痫前期有预测价值；分析网膜素与瘦素、血脂的相关性,初步探讨网膜素及瘦素在子痫前期发病中的可能机制。方法采用酶联免疫吸附试验法检测30例正常健康孕妇(A组)、30例子痫前期轻度孕妇(B组)、30例子痫前期重度孕妇(C组)的血浆Omentin及Leptin水平；同时测定所有受试者的脂生化指标。结果(1)子痫前期孕妇收缩压(SBP)、舒张压(DBP)。甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)均高于正常对照组,高密度脂蛋白胆固醇(HDL-C)低于正常对照组。(均P0.05)；(2)对照组、轻度子痫前期、重度子痫前期孕妇血浆Omentin浓度逐渐降低,分别为(400.05±211.9)ng/L,(307.03±230.34)ng/L,(155.84±20.71)ng/L],两两比较差异显著(P0.05);对照组、轻度子痫前期、重度子痫前期孕妇血浆Leptin水平浓度逐渐升高,分别为(37.38±15.16)ng/mL,(54.59±16.89) ng/mL,(110.25±31.45) ng/mL,两两比较差异显著(P0.05)；(3)血浆Omentin水平与HDL-C呈正相关,与BMI、收缩压呈负相关(P0.05)；(4)多元逐步回归分析显示,BMI、收缩压是影响血浆Omentin水平的重要因素(P0.05) 结论子痫前期孕妇存在脂代谢异常,子痫前期患者血浆网膜素浓度显著低于正常健康孕妇,患者病情越重,血浆中网膜素的浓度越低。相反,子痫前期患者的血浆瘦素浓度显著高于正常健康孕妇,血浆瘦素的浓度随着病情加重而升高。Pearson相关分析显示,血浆网膜素水平与瘦素呈负相关。提示网膜素及瘦素在子痫前期发生发展中的作用存在关联。如孕期联合测定血浆omentin及leptin,将有可能成为疾病的预测指标。
[Abstract]:Objective to detect the changes of plasma levels of omental (Omentin) and leptin (Leptin) in normal pregnancy and preeclampsia (preeclampsia) patients, and to explore their relationship with preeclampsia. So as to explore whether omentofin and leptin have predictive value in preeclampsia. To explore the possible mechanism of omentofin and leptin in preeclampsia. Methods the levels of plasma Omentin and Leptin in 30 normal pregnant women (group A), 30 cases of mild preeclampsia (group B) and 30 cases of severe preeclampsia (group C) were detected by enzyme-linked immunosorbent assay (Elisa). At the same time, the lipid biochemical indexes of all subjects were measured. Results (1) systolic blood pressure (SBP),) diastolic blood pressure (DBP).) in preeclampsia pregnant women Triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) was higher than normal control group and high density lipoprotein cholesterol (HDL-C) was lower than that of normal control group. (P0.05); (2) in the control group, the plasma Omentin concentrations of mild preeclampsia and severe preeclampsia decreased gradually, which were (400.05 卤211.9) ng/L, (307.03 卤230.34) ng/L, (155.84 卤20.71) ng/L, respectively. The difference was significant (P0.05). In the control group, the plasma Leptin levels of mild preeclampsia and severe preeclampsia were (37.38 卤15.16) ng/mL, (54.59 卤16.89) ng/mL, (110.25 卤31.45) ng/mL, respectively. The difference was significant (P0.05). (3) the plasma Omentin level was positively correlated with HDL-C and negatively correlated with BMI, systolic blood pressure (P0.05). (4) multivariate stepwise regression analysis showed that BMI, systolic blood pressure was an important factor affecting plasma Omentin level (P0.05). Conclusion there is abnormal lipid metabolism in preeclampsia pregnant women. The concentration of omentin in preeclampsia patients was significantly lower than that in normal pregnant women. On the contrary, the plasma leptin concentration in preeclampsia patients was significantly higher than that in normal pregnant women, and the plasma leptin concentration increased with the severity of the disease. Pearson correlation analysis showed that the plasma leptin level was negatively correlated with leptin. The results suggest that the role of omental hormone and leptin in the development of preeclampsia is associated with the development of preeclampsia. Combined determination of plasma omentin and leptin, during pregnancy may be a predictor of disease.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.244

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