孕妇血清sEng、sFlt-1及PLGF浓度变化对子痫前期的预测价值

发布时间：2019-01-19 19:52

【摘要】：目的探讨孕妇血清可溶性内皮因子(s Eng)、胎盘生长因子(PLGF)及可溶性血管内皮生长因子受体1(s FIt-1)的浓度变化对子痫前期的预测价值。方法选择子痫前期孕妇68例,其中重度子痫者28例,轻度子痫者40例,采用ELISA法检测血清s Eng、s FIt-1及PLGF水平,并与同期35例正常孕妇的血清上述指标进行比较,分析上述指标浓度改变对子痫前期的预测价值。结果重度子痫孕妇s Eng水平显著高于轻度子痫孕妇和正常孕妇,s FIt-1水平也显著高于轻度子痫孕妇和正常孕妇,PLGF水平显著低于轻度子痫孕妇和正常孕妇,轻度子痫孕妇s Eng和s FIt-1水平均显著高于正常孕妇,PLGF水平显著低于正常孕妇,差异均有统计学意义(P0.05)。结论孕中期s Eng、s FIt-1水平升高,PLGF水平降低可提示子痫前期。
[Abstract]:Objective to investigate the predictive value of serum soluble endothelial factor (s Eng), placental growth factor (PLGF) and soluble vascular endothelial growth factor receptor 1 (s FIt-1) in preeclampsia. Methods 68 cases of preeclampsia were selected, including 28 cases of severe eclampsia and 40 cases of mild eclampsia. Serum s Eng,s FIt-1 and PLGF levels were measured by ELISA method, and compared with those of 35 normal pregnant women in the same period. To analyze the predictive value of the above index concentration change in preeclampsia. Results the level of s Eng in severe eclampsia was significantly higher than that in mild eclampsia and normal pregnant women, and the level of s FIt-1 was significantly higher in severe eclampsia than that in mild eclampsia and normal pregnant women. The level of PLGF in severe eclampsia was significantly lower than that in mild eclampsia and normal pregnant women. The levels of s Eng and s FIt-1 in mild eclampsia women were significantly higher than those in normal pregnant women, and the levels of PLGF were significantly lower than those in normal pregnant women (P0.05). Conclusion the increase of s Eng,s FIt-1 level and the decrease of PLGF level in second trimester may indicate preeclampsia.
【作者单位】：福建医科大学附属第二医院妇产科;
【基金】：福建省泉州市科技计划项目(编号:Z[2012]0105)
【分类号】：R714.244

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