IVF-ET治疗后发生与未发生OHSS的PCOS患者相关指标及结局分析
发布时间：2019-01-29 21:30
【摘要】：目的：比较体外受精胚胎移植(IVF-ET)治疗后发生卵巢过度刺激综合征(OHSS)的多囊卵巢综合征(PCOS)患者与未发生OHSS的PCOS患者其相关指标及结局是否有差异。方法：回顾性分析2012年1月～2013年1月因不孕症就诊于我院生殖中心的87名PCOS患者,并将其分为两组,41名发生OHSS的PCOS患者定义为组A,46名未发生OHSS的PCOS患者定义为非OHSS组B。比较两组在接受超促排卵(COH)治疗前后相关指标及治疗结局。结果：组A的年龄、BMI、Gn总量、Gn天数均小于组B,差异有统计学意义(P0.05)；组A的LH/FSH、双侧卵巢基础窦卵泡数目、hCG日双侧卵巢大于14mm卵泡数目、hCG日双侧卵巢小于14mm卵泡数目、获卵数自均大于组B,差异有统计学意义(P0.05)；两组成熟卵母细胞率(%)、正常受精胚胎率(%)、优质胚胎率(%)、正常卵裂胚胎率(%)、首次FET宫内妊娠率均未见明显差异(P0.05)；组B新鲜胚胎移植与解冻胚胎移植宫内妊娠率未见明显差异(P0.05)。结论：年龄越小、体型越瘦、LH/FSH越大、双侧卵巢基础窦卵泡数越多的PCOS患者更容易在COH治疗后发生OHSS,虽然获卵数目更多,但其卵细胞及胚胎质量却未因此更高。PCOS患者无论发生OHSS与否,均不影响其首次解冻周期的宫内妊娠率。而未发生OHSS的PCOS患者其新鲜胚胎移植与解冻胚胎移植宫内妊娠率无显著差别。
[Abstract]:Aim: to compare the correlation indexes and outcomes of polycystic ovary syndrome (PCOS) with ovarian hyperstimulation syndrome (OHSS) after in vitro fertilization and embryo transfer (IVF-ET) between patients with polycystic ovary syndrome (PCOS) and those without OHSS (PCOS). Methods: from January 2012 to January 2013, 87 PCOS patients with infertility were analyzed and divided into two groups. 41 PCOS patients with OHSS were defined as group A. 46 PCOS patients without OHSS were defined as B in non OHSS group. The relative indexes and outcome were compared between the two groups before and after the treatment with hyperstimulation of ovulation (COH). Results: the age, total BMI,Gn and Gn days of group A were lower than that of group B (P0.05). In group A, the number of basal antral follicles in both ovaries of LH/FSH, the number of follicles in bilateral ovaries on hCG day was larger than that of 14mm follicles, and the number of ovarian follicles in both sides of ovary on hCG day was smaller than that of 14mm follicles, and the number of obtained eggs in group A was higher than that in group B (P0.05). The rate of matured oocytes (%), normal fertilization embryos (%), high quality embryos (%), normal cleavage embryos (%) and intrauterine pregnancy rate of first FET were not significantly different between the two groups (P0.05). There was no significant difference in intrauterine pregnancy rate between group B fresh embryo transfer and thawed embryo transfer (P0.05). Conclusion: the younger the age, the thinner the body, the larger the LH/FSH, the more the number of basic antral follicles in the bilateral ovaries is, the more OHSS, will occur in the patients with PCOS after COH treatment. However, the quality of eggs and embryos was not higher. No matter whether OHSS occurred or not, the rate of intrauterine pregnancy in PCOS patients was not affected by the first thawing cycle. However, there was no significant difference in intrauterine pregnancy rate between fresh embryo transfer and thawed embryo transfer in PCOS patients without OHSS.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.75;R714.8
本文编号：2417881
[Abstract]:Aim: to compare the correlation indexes and outcomes of polycystic ovary syndrome (PCOS) with ovarian hyperstimulation syndrome (OHSS) after in vitro fertilization and embryo transfer (IVF-ET) between patients with polycystic ovary syndrome (PCOS) and those without OHSS (PCOS). Methods: from January 2012 to January 2013, 87 PCOS patients with infertility were analyzed and divided into two groups. 41 PCOS patients with OHSS were defined as group A. 46 PCOS patients without OHSS were defined as B in non OHSS group. The relative indexes and outcome were compared between the two groups before and after the treatment with hyperstimulation of ovulation (COH). Results: the age, total BMI,Gn and Gn days of group A were lower than that of group B (P0.05). In group A, the number of basal antral follicles in both ovaries of LH/FSH, the number of follicles in bilateral ovaries on hCG day was larger than that of 14mm follicles, and the number of ovarian follicles in both sides of ovary on hCG day was smaller than that of 14mm follicles, and the number of obtained eggs in group A was higher than that in group B (P0.05). The rate of matured oocytes (%), normal fertilization embryos (%), high quality embryos (%), normal cleavage embryos (%) and intrauterine pregnancy rate of first FET were not significantly different between the two groups (P0.05). There was no significant difference in intrauterine pregnancy rate between group B fresh embryo transfer and thawed embryo transfer (P0.05). Conclusion: the younger the age, the thinner the body, the larger the LH/FSH, the more the number of basic antral follicles in the bilateral ovaries is, the more OHSS, will occur in the patients with PCOS after COH treatment. However, the quality of eggs and embryos was not higher. No matter whether OHSS occurred or not, the rate of intrauterine pregnancy in PCOS patients was not affected by the first thawing cycle. However, there was no significant difference in intrauterine pregnancy rate between fresh embryo transfer and thawed embryo transfer in PCOS patients without OHSS.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.75;R714.8
【共引文献】
相关期刊论文 前2条
1 王培;凌秀凤;李秀玲;卢莹;苏雁;张娟;赵纯;;促性腺激素释放激素拮抗剂在防治卵巢过度刺激综合征中的应用[J];中华临床医师杂志(电子版);2013年19期
2 葛明晓;陶莉莉;邓伟民;;卵巢过度刺激综合征的中西医诊疗研究进展[J];现代中西医结合杂志;2014年14期
相关硕士学位论文 前1条
1 乔明静;卵巢过度刺激征高危患者鲜胚移植与冻胚移植临床结局分析[D];华中科技大学;2013年
，本文编号：2417881
本文链接：https://www.wllwen.com/yixuelunwen/fuchankeerkelunwen/2417881.html
最近更新
教材专著
