妊娠晚期系统性红斑狼疮患者外周血淋巴细胞亚群的变化

发布时间：2019-01-30 21:35

【摘要】：目的:探讨妊娠晚期系统性红斑狼疮(SLE)患者外周血淋巴细胞亚群的变化及意义。方法:选取20例妊娠合并SLE患者和20例正常孕妇,采用流式细胞术检测第三孕期外周血T细胞、Th细胞、Tc细胞、B细胞、自然杀伤(NK)细胞和自然杀伤T(NKT)细胞水平,比较两组孕妇妊娠晚期外周血淋巴细胞亚群比率的变化,检验孕期SLEDAI分数与外周血淋巴细胞亚群比率的相关性。结果:与正常妊娠对照组比较,妊娠合并SLE组CD3+T细胞、CD3+CD8+Tc细胞和CD3-CD19+B细胞的比率明显升高(P0.05);而CD3+CD4+Th细胞、CD3-CD16+CD56+NK细胞及CD3+CD16+CD56+NKT细胞比率比较差异无统计学意义(P0.05)。妊娠合并SLE患者孕期SLEDAI分数与外周血B淋巴细胞及NK细胞的比率具有明显的正相关性(P0.01)。结论:妊娠合并SLE患者存在外周血淋巴细胞亚群比例失调,孕期SLEDAI分数与B细胞及NK细胞的比率具有明显相关性。
[Abstract]:Objective: to investigate the changes and significance of lymphocyte subsets in peripheral blood of (SLE) patients with late pregnancy systemic lupus erythematosus. Methods: peripheral blood T cells, Th cells, Tc cells, B cells, natural killer (NK) cells and natural killer T (NKT) cells were measured by flow cytometry in 20 pregnant women with SLE and 20 normal pregnant women. The ratio of peripheral blood lymphocyte subsets was compared between the two groups, and the correlation between SLEDAI score and peripheral blood lymphocyte subgroup ratio during pregnancy was examined. Results: compared with normal pregnancy control group, the ratio of CD3 T cells, CD3 CD8 Tc cells and CD3-CD19 B cells in pregnancy with SLE group was significantly increased (P0.05). The ratio of CD3 CD4 Th cells, CD3-CD16 CD56 NK cells and CD3 CD16 CD56 NKT cells was not significantly different (P0.05). There was a significant positive correlation between SLEDAI score and the ratio of B lymphocytes and NK cells in peripheral blood of pregnant women with SLE (P0.01). Conclusion: the proportion of lymphocyte subsets in peripheral blood of pregnant women with SLE is disproportion. The SLEDAI score in pregnancy is significantly correlated with the ratio of B cells and NK cells.
【作者单位】：广州医科大学附属第三医院妇产科;广州医科大学附属第三医院检验科;
【基金】：教育部博士点基金(新教师类)(编号:20124423120003) 广东省基金资助项目(编号:S2012040006672)
【分类号】：R714.25

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