黄体期添加滋肾育胎丸对体外受精-胚胎移植周期胚胎着床和妊娠结局的影响

发布时间：2019-02-11 12:11

【摘要】：目的:观察黄体支持时加用滋肾育胎丸对体外受精—胚胎移植(IVF-ET)周期胚胎着床和妊娠结局的影响。方法:行IVF-ET助孕符合纳入标准的不孕症患者共580例,随机分为对照组220例和研究组各360例,对照组予常规西药黄体支持,研究组加服滋肾育胎丸。结果:研究组和对照组临床妊娠率分别为58.06%和47.27%(P0.05);着床率分别为33.13%和25.76%(P0.01);早期先兆流产发生率分别为15.79%和25.53%(P0.05);流产发生率分别为9.09%和13.46%(P0.05);抱婴回家率分别为51.7%和40.45%(P0.01)。结论:黄体支持时加用滋肾育胎丸可提高IVF-ET周期的胚胎着床率、临床妊娠率和抱婴回家率,降低先兆流产发生率。对流产发生也有降低趋势,但由于流产样本量较少,差异尚无统计学意义,需更大样本的研究。
[Abstract]:Aim: to observe the effect of Zishen Yuewan on embryo implantation and pregnancy outcome in vitro fertilization-embryo transfer (IVF-ET) cycle with luteal support. Methods: a total of 580 infertile patients with IVF-ET were randomly divided into control group (n = 220) and study group (n = 360). The control group was given luteal support by routine western medicine, and the study group was treated with Zishen Yuet pills. Results: the clinical pregnancy rates of the study group and the control group were 58.06% and 47.27% (P0.05) respectively, and the implantation rates were 33.13% and 25.76% (P0.01), respectively. The incidence of early threatened abortion was 15.79% and 25.53% (P0.05) respectively; the incidence of abortion was 9.09% and 13.46% (P0.05); the rate of infantile home was 51.7% and 40.45% (P0.01). Conclusion: the application of Zishen Yuet Pill in luteal support can increase embryo implantation rate, clinical pregnancy rate and infantile home rate in IVF-ET cycle, and reduce the incidence of threatened abortion. The incidence of abortion also has a downward trend, but because the sample size of abortion is small, the difference is not statistically significant, so it is necessary to study the larger sample.
【作者单位】：安徽省立医院生殖医学中心;安徽中医药大学第一附属医院;
【基金】：国家自然科学基金(NO.81373671,NO.81370757) 韩明向全国名老中医药专家传承工作室基金
【分类号】：R714.8

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