宫颈癌术后HPV持续感染的危险因素及对免疫失衡的影响

发布时间：2019-02-17 12:45

【摘要】：目的分析宫颈癌术后人乳头状瘤病毒(HPV)持续感染的危险因素及其对免疫失衡的影响,为术后HPV持续感染的防治提供依据。方法回顾性分析2010年1月-2015年1月于医院接受手术治疗的220例HPV感染的宫颈癌患者的临床资料;分析术后HPV持续感染的危险因素及其对患者局部免疫功能的影响。结果 220例宫颈癌患者术后随访期间转阴180例,转阴率为81.82%,40例持续阳性,HPV持续阳性率为18.18%;单因素分析结果显示,宫颈癌家族病史、生殖道炎症、临床分期、术前HPV感染亚型、绝经情况、吸烟情况、术前HPV病毒负荷量与宫颈癌术后HPV持续感染具有相关性(P0.05);多因素logistic回归分析结果显示,生殖道炎症、术前HPV感染亚型、吸烟为宫颈癌术后HPV持续感染的危险因素;HPV持续阳性组免疫球蛋白A(IgA)、免疫球蛋白G(IgG)水平均低于非感染组(P0.05)。结论生殖道炎症、术前HPV感染亚型、吸烟为宫颈癌术后HPV持续感染的独立危险因素,宫颈癌术后HPV持续感染与患者局部免疫功能紊乱存在一定的相关性。
[Abstract]:Objective to analyze the risk factors of persistent infection of human papillomavirus (HPV) and its effect on immune imbalance after operation of cervical cancer, and to provide evidence for the prevention and treatment of persistent infection of HPV after operation. Methods the clinical data of 220 patients with cervical cancer infected with HPV were analyzed retrospectively from January 2010 to January 2015, and the risk factors of persistent infection of HPV and their influence on local immune function were analyzed. Results during the follow-up period, 180 cases of cervical cancer turned negative, the negative rate was 81.822% in 40 cases, and the persistent positive rate of HPV was 18.18%. Univariate analysis showed that the family history of cervical cancer, genital tract inflammation, clinical stage, preoperative HPV infection subtype, menopause, smoking status, preoperative HPV virus load was correlated with persistent HPV infection after cervical cancer (P0.05). Multivariate logistic regression analysis showed that genital tract inflammation, preoperative HPV infection subtype and smoking were the risk factors of persistent HPV infection after cervical cancer operation. The level of immunoglobulin A (IgA), immunoglobulin G (IgG) in HPV persistent positive group was lower than that in non infection group (P 0.05). Conclusion Reproductive tract inflammation, preoperative HPV infection subtype and smoking are independent risk factors for persistent HPV infection after cervical cancer surgery. There is a certain correlation between persistent HPV infection and local immune dysfunction in patients with cervical cancer.
【作者单位】：温州市人民医院妇产科;
【分类号】：R737.33

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