HIF-1α、VEGF、VEGFR-1、VEGFR-2在稽留流产患者绒毛组织中的表达

发布时间：2019-02-17 20:20

【摘要】：目的探讨低氧诱导因子(HIF-1α)、血管内皮生长因子(VEGF)及VEGF受体(VEGFR-1、VEGFR-2)在稽留流产(MA)绒毛组织中的表达及临床意义,探究MA发生中低氧对脑血管生成的影响。方法免疫组化SP法检测35例MA患者(研究组)以及32例正常早孕行人工流产者(对照组)绒毛组织的HIF-1α、VEGF、VEGFR-1、VEGFR-2的表达水平,并对结果进行统计分析。结果研究组与对照组绒毛组织中HIF-1α、VEGF、VEGFR-1、VEGFR-2均有表达。研究组中HIF-1α表达高于对照组(P0.05),VEGF、VEGFR-2表达明显低于对照组(P0.05)。对照组中HIF-1α与VEGF、VEGFR-1、VEGFR-2表达呈正相关性(P0.05),研究组中HIF-1α与VEGF、VEGFR-2表达呈负相关性(P0.05),与VEGFR-1表达无相关性。结论 HIF-1α在MA绒毛组织中表达上升,通过调节VEGF、VEGFR-2基因的转录,胎盘绒毛血管的生成减少,可能是MA发生的重要原因。
[Abstract]:Objective to investigate the expression and clinical significance of hypoxia inducible factor (HIF-1 伪), vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR-1,VEGFR-2) in (MA) villi of missed abortion. To explore the effect of middle hypoxia on cerebral vascular formation in MA. Methods the expression of HIF-1 伪 and VEGF,VEGFR-1,VEGFR-2 in chorionic villi of 35 MA patients (study group) and 32 normal early pregnant women (control group) were detected by immunohistochemical SP method. The results were statistically analyzed. Results the expression of HIF-1 伪 and VEGF,VEGFR-1,VEGFR-2 in chorionic villi of study group and control group were observed. The expression of HIF-1 伪 in the study group was higher than that in the control group (P0.05), and the expression of VEGF,VEGFR-2 was significantly lower than that in the control group (P0.05). There was a positive correlation between HIF-1 伪 and VEGF,VEGFR-1,VEGFR-2 expression in control group (P0.05), a negative correlation between HIF-1 伪 and VEGF,VEGFR-2 expression in study group (P0.05), but no correlation with VEGFR-1 expression. Conclusion the expression of HIF-1 伪 in MA chorionic villi is increased, and the decrease of placental villi angiogenesis by regulating the transcription of VEGF,VEGFR-2 gene may be an important cause of MA.
【作者单位】：安徽医科大学附属省立医院妇产科;安徽省妇幼保健院产科;
【基金】：安徽省科技攻关计划项目(编号:08010302101)
【分类号】：R714.21

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