血氨基末端脑利钠肽对初发高血压孕妇发生重度子痫前期的影响

发布时间：2019-02-21 20:51

【摘要】：目的探讨血氨基末端脑利钠肽(NT-pro BNP)对初发高血压孕妇发生重度子痫前期的影响,为其临床研究提供依据。方法选择120例初发高血压妊娠小于20周的孕妇作为研究对象,采用酶联免疫吸附法检测血NT-pro BNP水平,以20周后是否诊断为重度子痫前期分为重度组与非重度组,比较血NT-pro BNP水平差异。结果随访过程中发现120例妊娠孕妇中20例妊娠20周后表现为重度子痫前期,占16.7%。重度组孕周、收缩压及舒张压水平明显高于非重度组,差异有统计学意义(P0.05)。孕20周前重度组孕妇血NT-pro BNP水平明显高于非重度组孕妇,差异有统计学意义(P0.05);孕20周后重度组孕妇血NT-pro BNP水平明显升高,与孕20周前比较差异有统计学意义(P0.05),且明显高于孕20周后非重度组(P0.05);非重度组NT-pro BNP水平孕20周前后比较差异无统计学意义(P0.05)。NT-pro BNP预测重度子痫前期的灵敏度为75.0%,特异度为97.0%,阳性似然比为83.3%,阴性似然比为4.9%,诊断符合率为90.0%。ROC曲线的曲线下面积为0.895。结论重度子痫前期孕妇血NT-pro BNP明显升高,血NT-pro BNP对初发高血压孕妇发生重度子痫前期有较好的早期预测价值。
[Abstract]:Objective to investigate the effect of amino terminal brain natriuretic peptide (NT-pro BNP) on severe preeclampsia in primary hypertensive pregnant women. Methods 120 pregnant women with primary hypertension and less than 20 weeks of gestation were selected as the study subjects. The serum NT-pro BNP levels were detected by Elisa. The patients were divided into severe group and non-severe group according to whether they were diagnosed as severe preeclampsia after 20 weeks. Blood NT-pro BNP levels were compared. Results during the follow-up, 20 out of 120 pregnant women showed severe preeclampsia after 20 weeks of pregnancy, accounting for 16.7%. The levels of systolic blood pressure and diastolic blood pressure in severe group were significantly higher than those in non-severe group (P0.05). The serum NT-pro BNP level of severe pregnant women before 20 weeks of pregnancy was significantly higher than that of non-severe pregnant women (P0.05). After 20 weeks of gestation, the serum NT-pro BNP level in severe group was significantly higher than that before 20 weeks gestation (P0.05), and significantly higher than that in non-severe group after 20 weeks of gestation (P0.05). There was no significant difference in NT-pro BNP level before and after 20 weeks gestation in non-severe group (P0.05). The sensitivity, specificity and positive likelihood ratio of NT-pro BNP in predicting severe preeclampsia were 75.0, 97.0 and 83.3, respectively. The negative likelihood ratio was 4.9 and the area under the curve with diagnostic coincidence rate of 90.0%.ROC curve was 0.895. Conclusion Serum NT-pro BNP is significantly increased in severe preeclampsia, and serum NT-pro BNP is a good early predictor of severe preeclampsia in primary hypertensive women.
【作者单位】：海南省人民医院妇产科;
【分类号】：R714.24

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