阿托西班对反复着床失败后冻融周期囊胚移植妊娠结局的影响

发布时间：2019-02-26 16:45

【摘要】：目的:探讨胚胎反复着床失败(RIF)后冻融周期囊胚移植时使用缩宫素受体拮抗剂阿托西班对妊娠结局的影响。方法:回顾性分析2014年1月到2015年12月RIF,再次行冻融胚胎囊胚移植(bTET)的262例患者的临床资料,根据FET日是否使用阿托西班分为观察组和对照组,观察组(94例)于移植前0.5 h单剂量静脉推注小剂量阿托西班(6.75 mg/0.9 m L),对照组(168例)未使用阿托西班。分析比较两组间的临床妊娠率、胚胎着床率、多胎妊娠率、自然流产率、异位妊娠率及活产率。结果:观察组临床妊娠率(57.41%)、胚胎着床率(38.41%)、活产率(46.81%)均显著高于对照组(分别为41.12%、28.32%、33.93%),差异有统计学意义(P0.05);观察组自然流产率(14.82%)稍高于对照组(13.04%),多胎妊娠率(16.67%)和宫外孕率(3.70%)均稍低于对照组(分别为17.39%、5.79%),但差异均无统计学意义(P0.05)。结论:RIF患者FET日在囊胚移植前给予小剂量阿托西班预处理可明显改善临床妊娠结局。
[Abstract]:Aim: to investigate the effect of oxytocin receptor antagonist atoxipan on pregnancy outcome in frozen-thawed blastocyst transplantation after repeated implantation failure of (RIF). Methods: from January 2014 to December 2015, a retrospective analysis was made on the clinical data of 262 patients who underwent frozen-thawed blastocyst transfer (bTET) with RIF, again. The patients were divided into observation group and control group according to whether Atosiban was used on FET day or not. In observation group (n = 94), low dose atroxoban was injected intravenously 0.5 h before transplantation (6.75 mg/0.9 m L), control group, n = 168). The clinical pregnancy rate, embryo implantation rate, multiple pregnancy rate, spontaneous abortion rate, ectopic pregnancy rate and live rate were analyzed and compared between the two groups. Results: the clinical pregnancy rate (57.41%), embryo implantation rate (38.41%) and live birth rate (46.81%) in the observation group were significantly higher than those in the control group (41.12%, 28.32%, 33.93%, respectively). The difference was statistically significant (P0.05); The spontaneous abortion rate (14.82%) in the observation group was slightly higher than that in the control group (13.04%), and the multiple pregnancy rate (16.67%) and the extrauterine pregnancy rate (3.70%) in the observation group were slightly lower than those in the control group (17.39% and 5.79%, respectively). But the difference was not statistically significant (P0.05). Conclusion: low-dose atroxoban pretreatment before blastocyst transplantation can significantly improve the outcome of pregnancy in patients with RIF.
【作者单位】：湖北省妇幼保健院生殖医学中心;
【分类号】：R714.8

【相似文献】