探讨血清HE4、CA125及ROMA指数在上皮性卵巢癌中的诊断价值
发布时间：2019-03-06 19:31
【摘要】：目的：探讨血清人附睾蛋白4(HE4)与糖类抗原CA125及ROMA指数在卵巢癌妇女中的诊断价值。方法：采用微粒子化学发光法检测184例上皮性卵巢癌患者血清标本HE4和CA125,并结合绝经状态计算出ROMA指数；以132例卵巢良性疾病和107例健康体检者作为对照组。结果：1.HE4检测水平在绝经前后患者中均为恶性组高于健康对照组和卵巢良性疾病组,但对照组与良性疾病组无统计学差异。而CA125的检测水平在三组的比较中,差异均有统计学意义(P0.05)。2.HE4的诊断特异度及阳性预测值高于CA125,将其联合检测诊断灵敏度、诊断特异度分别为92.39%和81.06%,并且诊断符合率为87.66%均高于单项检测。3.在病理分期中HE4在Ⅰ期+Ⅱ期中的阳性率高于CA125,CA125在Ⅲ期+Ⅳ期中的阳性率高于HE4,两者联合检测在Ⅰ期+Ⅱ期中的阳性率为92.68%；4.HE4、CA125单独检测及联合检测,阳性率在绝经前后、维族与汉族之间无明显差异；年龄因素除CA125的阳性率在≤45岁与45岁中无统计学意义外,另外两者的阳性率均有统计学差异。5.联合检测HE4与CA125用Fisher判别分析判别卵巢癌正确率分别为绝经前组78.82%(67/85),绝经后组79.80%(79/99)。6.绝经前组中ROMA指数诊断灵敏度、特异度分别为90.59%、89.06%；绝经后组中ROMA指数的灵敏度、特异度分别为91.92%、86.76%,两组之间差异无统计学意义x2=0.26,P=0.83。7.CA125、HE4、ROMA指数的曲线下面积在绝经前后组中均为HE4与ROMA的曲线下面积大于CA125。结论：1.CA125对卵巢良恶性疾病的区分不如HE4好,HE4应用于上皮性卵巢癌可降低漏诊率提高早期诊断能力,将其联合检测对卵巢癌的诊断价值更高。2.ROMA指数适合用于评估上皮性卵巢癌的风险性,从而提高诊断率。
[Abstract]:Aim: to investigate the diagnostic value of serum human epididymal protein 4 (HE4), carbohydrate antigen CA125 and ROMA index in women with ovarian cancer. Methods: the serum HE4 and CA125, were measured by microparticle chemiluminescence in 184 patients with epithelial ovarian cancer and the ROMA index was calculated in combination with menopause status, and the control group consisted of 132 benign ovarian diseases and 107 healthy controls. Results: the level of 1.HE4 was higher in the malignant group than that in the healthy control group and the benign ovarian disease group before and after menopause, but there was no significant difference between the control group and the benign disease group. 2. The diagnostic specificity and positive predictive value of HE4 were higher than those of CA125, and the sensitivity of combined detection of CA125 was higher than that of HE4 in the comparison of the three groups (P0.05). 2. The diagnostic specificity and positive predictive value of HE4 were higher than that of CA125,. The specificity of diagnosis was 92.39% and 81.06% respectively, and the diagnostic coincidence rate of 87.66% was higher than that of single detection. 3. The positive rate of HE4 in stage 鈪，
本文编号：2435829
[Abstract]:Aim: to investigate the diagnostic value of serum human epididymal protein 4 (HE4), carbohydrate antigen CA125 and ROMA index in women with ovarian cancer. Methods: the serum HE4 and CA125, were measured by microparticle chemiluminescence in 184 patients with epithelial ovarian cancer and the ROMA index was calculated in combination with menopause status, and the control group consisted of 132 benign ovarian diseases and 107 healthy controls. Results: the level of 1.HE4 was higher in the malignant group than that in the healthy control group and the benign ovarian disease group before and after menopause, but there was no significant difference between the control group and the benign disease group. 2. The diagnostic specificity and positive predictive value of HE4 were higher than those of CA125, and the sensitivity of combined detection of CA125 was higher than that of HE4 in the comparison of the three groups (P0.05). 2. The diagnostic specificity and positive predictive value of HE4 were higher than that of CA125,. The specificity of diagnosis was 92.39% and 81.06% respectively, and the diagnostic coincidence rate of 87.66% was higher than that of single detection. 3. The positive rate of HE4 in stage 鈪，
本文编号：2435829
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