孕妇发砷含量及相关因素与新生儿先天性心脏病的关系研究
发布时间：2019-03-08 20:06
【摘要】：目的探讨孕妇头发砷含量及其相关影响因素与新生儿先天性心脏病(CHD)的关系,为临床预防胎儿CHD提供参考依据。方法选取本院2012年1月至2014年1月收治的确诊为胎儿CHD的孕妇50例作病例组,再选取50例本院同期收治的健康孕妇作为对照组。应用电感耦合等离子质谱法测定两组患者头发中砷含量,并对患者进行问卷调查,分析胎儿CHD与孕妇发砷含量及其他相关因素的关系。结果病例组与对照组孕妇发砷含量差异具有统计学意义(P0.05);复杂型CHD孕妇的发砷含量显著高于简单型CHD孕妇(P0.05),与是否合并心外畸形无显著相关(P0.05);相关因素分析结果显示,孕妇发砷含量、孕妇接触有毒物质及化学物质、丈夫吸烟、孕妇饮酒5个因素与胎儿CHD显著相关(P0.05)。结论孕妇发砷含量增高以及接触化学物质、有毒物质、有饮酒习惯、丈夫吸烟等因素均可能导致胎儿CHD的发生。
[Abstract]:Objective to investigate the relationship between arsenic content in hair of pregnant women and neonatal congenital heart disease (CHD) in order to provide reference for clinical prevention of fetal CHD. Methods from January 2012 to January 2014, 50 pregnant women diagnosed as fetal CHD were selected as case group, and 50 healthy pregnant women who were admitted to our hospital at the same time were selected as control group. The arsenic content in hair of two groups was determined by inductively coupled plasma mass spectrometry (ICP-MS), and the relationship between fetal CHD and hair arsenic content in pregnant women and other related factors was analyzed by questionnaire survey. Results the arsenic content in hair of pregnant women with complex CHD was significantly higher than that of pregnant women with simple CHD (P0.05), and there was no significant correlation between the content of arsenic in the hair of pregnant women and patients with extracardiac malformations (P0.05), but there was no significant difference between the two groups (P0.05). The results of correlation factor analysis showed that 5 factors, such as the content of arsenic in the hair of pregnant women, the exposure of pregnant women to toxic substances and chemicals, smoking by husband and drinking alcohol in pregnant women, were significantly correlated with fetal CHD (P0.05). Conclusion the increase of arsenic content in the hair of pregnant women and exposure to chemicals, toxic substances, drinking habits, smoking of husband and other factors may lead to the occurrence of fetal CHD.
【作者单位】： 莱芜市妇幼保健院妇产科;
【分类号】：R714.53
，
本文编号：2437158
[Abstract]:Objective to investigate the relationship between arsenic content in hair of pregnant women and neonatal congenital heart disease (CHD) in order to provide reference for clinical prevention of fetal CHD. Methods from January 2012 to January 2014, 50 pregnant women diagnosed as fetal CHD were selected as case group, and 50 healthy pregnant women who were admitted to our hospital at the same time were selected as control group. The arsenic content in hair of two groups was determined by inductively coupled plasma mass spectrometry (ICP-MS), and the relationship between fetal CHD and hair arsenic content in pregnant women and other related factors was analyzed by questionnaire survey. Results the arsenic content in hair of pregnant women with complex CHD was significantly higher than that of pregnant women with simple CHD (P0.05), and there was no significant correlation between the content of arsenic in the hair of pregnant women and patients with extracardiac malformations (P0.05), but there was no significant difference between the two groups (P0.05). The results of correlation factor analysis showed that 5 factors, such as the content of arsenic in the hair of pregnant women, the exposure of pregnant women to toxic substances and chemicals, smoking by husband and drinking alcohol in pregnant women, were significantly correlated with fetal CHD (P0.05). Conclusion the increase of arsenic content in the hair of pregnant women and exposure to chemicals, toxic substances, drinking habits, smoking of husband and other factors may lead to the occurrence of fetal CHD.
【作者单位】： 莱芜市妇幼保健院妇产科;
【分类号】：R714.53
，
本文编号：2437158
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