微小染色体维持蛋白在妇科恶性肿瘤中的研究进展
发布时间：2019-03-11 08:04
【摘要】：微小染色体维持蛋白(minichromosome maintenance proteins, MCM蛋白)是真核生物DNA复制的主要调节因子,在DNA复制起始和延伸过程中发挥重要作用。其表达于有增殖活性的细胞中,并保证一次细胞周期中DNA的复制只发生一次,当由于某些因素引起MCM蛋白发生异常时,处于静止期的细胞重新进入细胞周期,DNA异常复制,最终导致肿瘤的发生,所以MCM蛋白被认为是一种新的肿瘤标志物。近年来,有研究发现MCM蛋白与妇科恶性肿瘤的发生、发展密切相关,并与肿瘤的靶向治疗有关,从而为妇科恶性肿瘤的治疗带来新的希望。该文就MCM蛋白在妇科恶性肿瘤中的研究进展进行综述。
[Abstract]:Microchromosome maintenance protein (minichromosome maintenance proteins, MCM) is a major regulator of DNA replication in eukaryotes and plays an important role in the initiation and extension of DNA replication. It is expressed in the proliferative cells and ensures that the replication of DNA occurs only once in a cell cycle. When the MCM protein is abnormal due to some factors, the cells in the quiescent phase re-enter the cell cycle, and the abnormal replication of DNA occurs in the cell cycle. MCM protein is considered to be a new tumor marker. In recent years, it has been found that MCM protein is closely related to the occurrence and development of gynecological malignant tumors, and related to the targeted treatment of gynecological malignancies, thus bringing new hope for the treatment of gynecological malignant tumors. This article reviews the research progress of MCM protein in gynecological malignant tumors.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.3
[Abstract]:Microchromosome maintenance protein (minichromosome maintenance proteins, MCM) is a major regulator of DNA replication in eukaryotes and plays an important role in the initiation and extension of DNA replication. It is expressed in the proliferative cells and ensures that the replication of DNA occurs only once in a cell cycle. When the MCM protein is abnormal due to some factors, the cells in the quiescent phase re-enter the cell cycle, and the abnormal replication of DNA occurs in the cell cycle. MCM protein is considered to be a new tumor marker. In recent years, it has been found that MCM protein is closely related to the occurrence and development of gynecological malignant tumors, and related to the targeted treatment of gynecological malignancies, thus bringing new hope for the treatment of gynecological malignant tumors. This article reviews the research progress of MCM protein in gynecological malignant tumors.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.3
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