解冻后胚胎质量对其早期临床妊娠结局的影响

发布时间：2019-03-17 07:35

【摘要】：目的:探讨人类冻融胚胎质量对早期临床妊娠结局的影响。方法:回顾性分析了2012年3月至2015年6月期间,在我院生殖中心进行玻璃化冷冻的人类冻融胚胎移植(Frozen-thawed Embryos Transfer,FET)的738个周期的患者的相关资料,分别按照移植优质胚胎的数量、卵裂球损伤的程度、移植胚胎中是否含8细胞胚胎以及含8细胞胚胎的数目,将其分为4类组,分别比较各分类组间的早期临床妊娠率和多胎妊娠率之间的差异。结果:(1)移植2枚优质胚胎组早期临床妊娠率均高于移植0枚优质胚胎组和移植1枚优质胚胎组(P0.05),并且与移植3枚优质胚胎组是早期临床妊娠率基本相同;各组间的多胎妊娠率无统计学差异;(2)移植胚胎完整组、损伤组、损伤混合组各组间的早期临床妊娠率、多胎妊娠率均无统计学差异;(3)移植8细胞胚胎组的早期临床妊娠率显著高于移植6-7或9-13细胞胚胎组(P0.05),且各组间的多胎妊娠率无统计学差异。(4)移植2枚8细胞胚胎组的种植率、早期临床妊娠率显著高于移植0枚8细胞胚胎组和移植1枚8细胞胚胎组(P0.05);移植3枚8细胞胚胎组的多胎妊娠率显著高于移植0枚8细胞胚胎组(P0.05),其余组间差异无统计学意义。结论：FET中移植的优质胚胎数目和8细胞胚胎数目是影响早期临床妊娠率和多胎妊娠率的重要因素;胚胎损伤对早期临床妊娠率和多胎妊娠率无明显影响。因此,FET时移植至少1枚优质胚胎或1枚8细胞胚胎,既可以保证其早期临床妊娠率,同时又可以降低多胎妊娠率。
[Abstract]:Objective: to investigate the effect of human frozen-thawed embryo quality on the outcome of early pregnancy. Methods: the data of 738 cycles of vitrification frozen human frozen embryo transfer (Frozen-thawed Embryos Transfer,FET) from March 2012 to June 2015 in our hospital were retrospectively analyzed. They were divided into four groups according to the number of high-quality embryos transferred, the degree of blastomere injury, and whether the transferred embryos contained 8-cell embryos and the number of 8-cell embryos. The differences of early clinical pregnancy rate and multiple pregnancy rate among different groups were compared. Results: (1) the early pregnancy rate of the two high-quality embryos group was higher than that of 0 high-quality embryo group and 1 high-quality embryo group (P0.05), and the rate of early clinical pregnancy was basically the same as that of the three high-quality embryo group. (2) there was no significant difference in early clinical pregnancy rate and multiple pregnancy rate among the groups of intact embryo transfer group, injury-mixed group and multiple pregnancy group; (2) there was no significant difference in early clinical pregnancy rate and multiple pregnancy rate among the groups of intact embryo transfer group and injury mixed group. (3) the rate of early clinical pregnancy in 8-cell embryo transplantation group was significantly higher than that in 6 / 7 or 9 / 13 cell embryo transplantation group (P0.05). (4) the early clinical pregnancy rate of 2 8-cell embryos transplanted group was significantly higher than that of 0 8-cell embryo transplantation group and 1 8-cell embryo transplantation group (P0.05). The multiple pregnancy rate of 3 8-cell embryos transplanted group was significantly higher than that of 0 8-cell embryo transplantation group (P0.05), but there was no significant difference among the other groups. Conclusion: the number of high-quality embryos and the number of 8-cell embryos transferred in FET are important factors affecting early clinical pregnancy rate and multiple pregnancy rate, but embryo injury has no significant effect on early clinical pregnancy rate and multiple pregnancy rate. Therefore, the transfer of at least one high-quality embryo or one 8-cell embryo during FET can not only guarantee the early clinical pregnancy rate, but also reduce the multiple pregnancy rate.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R714.8

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