宫内缺氧胎儿脐血流超声参数与母体、胎儿氧化应激损伤的关系

发布时间：2019-03-18 20:28

【摘要】：目的探究宫内缺氧胎儿脐血流超声参数与母体、胎儿氧化应激损伤的相关性。方法分娩的产妇200例,根据新生儿Apgar评分分为正常组与缺氧组。孕龄24~30周、31~36周、37~41周时分别记录孕产妇彩超检测的脐血流超声参数,检测脐带血中氧化应激产物、胎盘组织中氧化应激产物与相关细胞凋亡分子的水平,并分析其与超声参数的相关性。结果不同孕周缺氧组脐血流超声参数阻力指数(RI)、搏动指数(PI)、收缩期最大血流速度/舒张末期血流速度(S/D)均高于正常组(P均0.05);与正常组比较,缺氧组脐带血与胎盘组织中氧化应激产物丙二醛(MDA)、氧化低密度脂蛋白(ox-LDL)、8-异前列腺素(8-ios)、热休克蛋白70(HSP-70),胎盘组织中脂肪酸合成酶(Fas)、脂肪酸合成酶配体(FasL)、Bcl-2相关X蛋白(Bax)水平高(P均0.05),胎盘组织中B细胞淋巴瘤/白血病基因2(Bcl-2)、X连锁凋亡抑制蛋白(XIAP)水平低(P均0.05)。RI、PI、S/D分别与脐带血和胎盘组织中MDA、ox-LDL、8-ios、HSP-70及胎盘组织中Fas、FasL、Bax水平呈正相关(P均0.05),与胎盘组织中Bcl-2、XIAP呈负相关(P均0.05)。结论宫内缺氧胎儿脐血流超声参数出现明显异常,其与母体、胎儿氧化应激损伤程度有相关性。
[Abstract]:Objective to investigate the relationship between fetal umbilical cord blood flow parameters and fetal oxidative stress injury during intrauterine hypoxia. Methods two hundred parturients were divided into normal group and hypoxic group according to neonatal Apgar score. At 24, 30, 31, 37, 41 weeks of gestation, the ultrasonic parameters of umbilical cord blood were recorded, and the levels of oxidative stress products in umbilical cord blood, oxidative stress products in placental tissue and related apoptotic molecules were detected. The correlation between ultrasonic parameters and ultrasonic parameters was analyzed. Results the (RI), pulsatility index of umbilical cord blood flow in different gestational weeks was significantly higher than that in normal group (P < 0.05). The maximal systolic velocity / end diastolic velocity of (PI), in hypoxia group was significantly higher than that in normal group (P < 0.05). Compared with the normal group, the oxidative stress products of umbilical cord blood and placenta in hypoxia group were oxidized low density lipoprotein (ox-LDL), 8-isoprostaglandin (8-ios), heat shock protein 70 (HSP-70) by malondialdehyde (MDA),). Fatty acid synthetase (Fas), fatty acid synthetase ligand (FasL), Bcl-2-associated X protein (Bax) level in placental tissue was higher than that in placental tissue. B-cell lymphoma / leukemia gene 2 (Bcl-2) was found in placental tissue. Ri and PI,S/D were associated with MDA,ox-LDL,8-ios,HSP-70 in umbilical cord blood and placental tissue and Fas,FasL, in placental tissue, respectively. The expression of X-linked inhibitor of apoptosis protein (XIAP) was lower than that in umbilical cord blood, placental tissue and placental tissue. There was a positive correlation between Bax level and a negative correlation with Bcl-2,XIAP in placental tissue (all P0.05). Conclusion the ultrasonic parameters of fetal umbilical cord blood flow in intrauterine hypoxia are abnormal, which is correlated with the degree of fetal oxidative stress injury.
【作者单位】：青海红十字医院;
【基金】：青海省卫生计生指导性科研课题(2016-wjqn-84)
【分类号】：R714.5

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