人乳头状瘤病毒感染对宫颈上皮内瘤变及宫颈癌患者组蛋白去乙酰化酶1及基质金属蛋白酶表达的影响研究

发布时间：2019-03-20 12:03

【摘要】：目的研究人乳头状瘤病毒(HPV)感染对宫颈上皮内瘤变及宫颈癌患者组蛋白去乙酰化酶1(HDAC1)及基质金属蛋白酶(MMPs)表达的影响,为宫颈上皮内瘤变及宫颈癌的诊治提供参考依据。方法选取2014年4月-2016年3月医院收治39例宫颈癌患者为A组,39例宫颈上皮内瘤变患者为B组,39名健康妇女为C组,检测与比较3组研究者组织HDAC1及MMP指标表达情况,并比较A组与B组中不同HPV感染者的上述指标表达水平。结果 A组患者组织HDAC1及MMP-2、MMP-3、MMP-7、MMP-9阳性表达率为71.79%及66.67%、64.10%、64.10%、66.67%,均高于B组患者38.46%及43.59%、38.46%、30.77%、35.90%,C组5.13%及7.69%、2.56%、2.56%、5.13%,B组患者阳性表达率则高于C组,A组和B组中HPV感染者阳性表达率高于HPV阴性者,且B组中高度病变者阳性表达率高于低度病变者,差异有统计学意义(P0.05)。结论HPV感染对宫颈上皮内瘤变及宫颈癌患者组织的HDAC1及MMP指标表达影响较大,因此应重视对上述指标的监测与控制。
[Abstract]:Objective to study the effect of human papillomavirus (HPV) infection on the expression of histone deacetylase 1 (HDAC1) and matrix metalloproteinase (MMPs) in cervical intraepithelial neoplasia and cervical cancer. To provide a reference for the diagnosis and treatment of cervical intraepithelial neoplasia and cervical cancer. Methods from April 2014 to March 2016, 39 patients with cervical cancer, 39 patients with cervical intraepithelial neoplasia, 39 patients with cervical intraepithelial neoplasia and 39 healthy women as group C, were selected as group A, 39 patients with cervical intraepithelial neoplasia and 39 healthy women as group C. The expression of HDAC1 and MMP in the tissues of three groups of researchers was measured and compared. The expression levels of the above indexes were compared between group A and group B with different HPV infection. Results the positive expression rates of HDAC1 and MMP-2,MMP-3,MMP-7,MMP-9 in group A were 71.79% and 66.67%, 64.10%, 64.10%, 66.67%, respectively, which were higher than those in group B (38.46% and 43.59%). 38.46%, 30.77%, 35.90%, 5.13% and 7.69%, 2.56%, 2.56%, 5.13% in group C, the positive expression rate in group B was higher than that in group C. The positive expression rate of HPV infection in group A and B was higher than that in group A and group B, and the positive rate in group B was higher than that in group B (P0.05). Conclusion HPV infection has a significant effect on the expression of HDAC1 and MMP in cervical intraepithelial neoplasia and cervical cancer, so we should pay more attention to the monitoring and control of these indexes.
【作者单位】：内蒙古医科大学附属医院妇产科;
【基金】：内蒙古自治区自然科学基金资助项目(2014MS0849)
【分类号】：R737.33

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