辅助生殖技术出生儿童的青春发育情况调查

发布时间：2019-04-07 15:34

【摘要】：目的了解辅助生殖技术(ART)出生儿童青春发育状况。方法回顾性收集1994~2003年北京大学第三医院ART出生儿童的青春发育资料,以"2010年中国学生体质健康调查"横断面研究结果为对照数据,比较二者首次遗精或月经初潮年龄;观察ART出生儿童中超重/肥胖者青春发育情况,并探讨青春发育与体重指数的相关性。结果纳入ART出生儿童200例,获得有效数据72例,随访率36.0%,其中男性41例,女性31例。ART出生儿童首次遗精平均年龄为13.9岁(95%CI:13.7~14.3岁),月经初潮平均年龄为12.2岁(95%CI:11.8~12.6岁),ART出生儿童首次遗精年龄和月经初潮年龄与正常对照比较差异均无统计学意义。ART出生的男女儿童中超重/肥胖者与正常体重者的首次遗精年龄或月经初潮年龄比较差异无统计学意义。ART出生的儿童超重率、肥胖率与北京市青少年超重率、肥胖率比较差异无统计学意义。ART出生的儿童首次遗精年龄和月经初潮年龄与体重指数均无明显相关性。结论 ART出生儿童青春期发育未出现延迟或提前,与正常对照人群一致;ART出生儿童青春期发育与其青春期体重指数无显著相关性。
[Abstract]:Objective to investigate the adolescent development of children born with assisted reproductive technology (ART). Methods the data of adolescent development of ART-born children in the third Hospital of Peking University from 1994 to 2003 were collected retrospectively. The cross-sectional data of "physical Health Survey of Chinese students in 2010" were used as control data to compare the age of first spermatorrhea or menarche between the two groups. To investigate the relationship between adolescent development and body mass index (BMI) in overweight / obese children born with ART. Results A total of 72 ART-born children were enrolled in the study. The follow-up rate was 36. 0%, including 41 males and 31 females. The average age of art-born children was 13.9 years old (95%CI:13.7~14.3 years), and the follow-up rate was 36.0%. The average age of menarche is 12.2 years (95%CI:11.8~12.6). There was no significant difference in the age of first spermatogenesis and menarche between ART-born children and normal controls. The age of first spermatogenesis or menarche in overweight / obese children with art birth and those with normal weight were not significantly different. There was no statistical difference between the two groups. The rate of overweight in art-born children was not statistically significant. There was no significant difference between obesity rate, overweight rate and obesity rate among adolescents in Beijing. There was no significant correlation between the age of first spermatogenesis and menarche age and body mass index (BMI) in art-born children. Conclusion there is no delay or advance in puberty development in ART-born children, and there is no significant correlation between puberty development and puberty body mass index in ART-born children.
【作者单位】：北京大学第三医院儿科;北京大学儿童青少年卫生研究所;
【分类号】：R714.8

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