改良超长方案对多囊卵巢综合征不孕患者子宫内膜容受性的改善作用研究

发布时间：2019-04-08 11:56

【摘要】：目的探讨改良超长方案对多囊卵巢综合症(PCOS)不孕患者子宫内膜容受性的影响。方法选择PCOS不孕患者100例,根据随机数字表法分为改良组和对照组,每组50例。改良组给予改良超长方案,对照组给予标准长效长方案。经阴道超声检查观察排卵情况及治疗前后子宫内膜变化情况;着床窗口期对内膜间质和腺体分别进行整合素αv、β3及雌激素受体(ER)、孕激素受体(PR)、雄激素受体(AR)的免疫组织化学染色;治疗后对治疗总有效率进行Salle评分。结果改良组排卵周期数明显多于对照组,排卵率明显高于对照组(P0.01);改良组、对照组治疗后子宫内膜厚度均较治疗前明显变厚(P0.01),改良组治疗后子宫内膜厚度明显厚于对照组(P0.01)。各组治疗后内膜血流量均有增加趋势,改良组治疗后内膜血流量高于对照组(P0.05)。改良组治疗后Salle评分明显低于对照组(P0.01)。结论改良超长方案可有效提高PCOS患者排卵率、改善子宫内膜容受性,值得临床推广。
[Abstract]:Objective to investigate the effect of modified ultra-long regimen on endometrial receptivity in (PCOS) infertility patients with polycystic ovary syndrome (PCOS). Methods A total of 100 PCOS infertile patients were divided into two groups according to the method of random number table: improved group and control group, 50 cases in each group. The improved group was given the modified long-term regimen, and the control group was given the standard long-term plan. Transvaginal ultrasound was used to observe ovulation and endometrial changes before and after treatment. Immunohistochemical staining of integrin 伪 v, 尾 3 and estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR) were performed in endometrial interstitial and glandular stroma during implantation window, and the total effective rate was evaluated by Salle after treatment. Results the number of ovulation cycles in the improved group was significantly higher than that in the control group, and the ovulation rate was significantly higher than that in the control group (P0.01). In the improved group, the endometrial thickness in the control group was significantly thicker than that in the control group after treatment (P0.01), and the endometrial thickness in the modified group was significantly thicker than that in the control group after treatment (P0.01). After treatment, the intimal blood flow in the improved group was higher than that in the control group (P0.05). After treatment, the Salle score in the improved group was significantly lower than that in the control group (P0.01). Conclusion the modified super-long regimen can effectively improve ovulation rate and endometrial receptivity in patients with PCOS, which is worthy of clinical application.
【作者单位】：陕西省汉中市三二零一医院妇产科;
【分类号】：R711.75;R711.6

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