Ⅱ期及以上卵巢上皮性癌临床复发的相关影响因素分析

发布时间：2019-04-10 17:28

【摘要】：目的:探讨影响上皮性卵巢癌术后复发的相关因素。方法:回顾分析天津中心妇产科医院收治且随访资料完整的132例上皮性卵巢癌患者的临床资料,其中术后复发56例(复发组),未复发76例(对照组)。比较两组患者的年龄、临床分期、组织分级、残留病灶、腹水情况、术前HE4值、有无新辅助化疗、术后2月CA125值、术后化疗方式等,采用单因素及多因素分析研究各因素与复发的关系。结果:单因素分析结果显示,临床分期、残留病灶1cm、腹水、术前HE4值、术后2月CA12535U/L及组织分级是影响卵巢上皮性癌患者复发的因素;多变量分析结果显示,临床分期、病理分级、腹水和术前HE4是影响患者复发的独立因素;年龄、组织学类型及化疗方案与上皮性卵巢癌复发无关。结论:有腹水、低分化的晚期上皮性卵巢癌、且术前HE4400pmol/L,术后2月CA12535U/L是术后复发的高危因素,应加强完善术后辅助治疗,降低复发风险,并严密随访,以便更早发现肿瘤复发。
[Abstract]:Objective: to investigate the risk factors of postoperative recurrence of epithelial ovarian cancer (EOC). Methods: the clinical data of 132 patients with epithelial ovarian cancer treated in Tianjin Central Obstetrics and Gynecology Hospital were retrospectively analyzed. There were 56 cases of recurrence (recurrence group) and 76 cases of non-recurrence (control group). The age, clinical stage, histological grade, residual lesion, ascites, preoperative HE4 value, neoadjuvant chemotherapy, CA125 value 2 months after operation, postoperative chemotherapy mode and so on were compared between the two groups. Univariate and multivariate analysis was used to study the relationship between each factor and recurrence. Results: univariate analysis showed that clinical stage, residual focus 1 cm, ascites, preoperative HE4 value, postoperative CA12535U/L and histological grade 2 months after operation were the factors affecting recurrence of ovarian epithelial carcinoma. Multivariate analysis showed that clinical stage, pathological grade, ascites and preoperative HE4 were independent factors affecting recurrence, while age, histological type and chemotherapy regimen were not associated with recurrence of epithelial ovarian cancer. Conclusion: advanced epithelial ovarian cancer with ascites and low differentiation, and preoperative HE4400pmol/L, 2 months after CA12535U/L is a high risk factor for postoperative recurrence, should be strengthened to improve postoperative adjuvant treatment, reduce the risk of recurrence, and close follow-up. In order to detect tumor recurrence earlier.
【作者单位】：天津医科大学;天津中心妇产科医院;
【分类号】：R737.31

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