34例子宫内膜癌合并结直肠癌双原发癌的临床特征及其与Lynch综合征关系分析

发布时间：2019-04-12 19:42

【摘要】：目的:探讨子宫内膜癌合并结直肠癌双原发癌患者的临床表现、治疗方法及其预后,并分析与Lynch综合征关系。方法:回顾性分析中国医学科学院肿瘤医院34例子宫内膜癌合并结直肠癌双原发癌患者的临床病理资料。结果:34例患者的中位发病年龄为51.5(39~76)岁,64.7%(22/34)有肿瘤家族史,子宫内膜样腺癌占79.4%(27/34)。34例中33例双原发癌患者行手术治疗,19例子宫内膜癌、17例结直肠癌术后行放化疗。2年生存率为84.3%,5年生存率为63.1%。结论:子宫内膜癌合并结直肠癌双原发癌患者多具有肿瘤家族史、发病年龄早、预后与散发型结直肠癌相近,部分患者符合Lynch综合征。
[Abstract]:Aim: to investigate the clinical manifestation, treatment and prognosis of patients with endometrial carcinoma complicated with colorectal cancer and to analyze the relationship between the clinical manifestation and Lynch syndrome. Methods: the clinical and pathological data of 34 patients with endometrial carcinoma complicated with double primary carcinoma of colorectal cancer were retrospectively analyzed in the Cancer Hospital, Chinese Academy of Medical Sciences (CAS). Results: the median age of onset was 51.5 (39 / 76) years old, 64.7% (22 / 34) had family history of tumor and 79.4% (27 / 34) had endometrioid adenocarcinoma. 19 cases of endometrial carcinoma and 17 cases of colorectal cancer were treated with radiotherapy and chemotherapy. The 2-year survival rate was 84.3% and the 5-year survival rate was 63.1%. Conclusion: most of the patients with endometrial carcinoma complicated with colorectal cancer have family history, early onset age, similar prognosis and sporadic colorectal cancer. Some of the patients are in accordance with Lynch syndrome.
【作者单位】： 中国医学科学院肿瘤医院妇瘤科;北京协和医学院;
【分类号】：R737.33;R735.34

【共引文献】

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