低分子肝素联合主动免疫治疗不明原因复发性自然流产的效果

发布时间：2019-04-19 00:19

【摘要】：目的:观察低分子肝素联合主动免疫治疗不明原因反复流产的作用。方法:2009年1月至2012年12月期间,我院收治的80例原因不明性反复自然流产(unexplained recurrent spontaneous abortion,URSA)患者,经知情同意后分为观察组(n=45)和对照组(n=35)。对照组患者采取主动免疫疗法,妊娠后联合常规保胎治疗;观察组患者在上述治疗基础上,联合注射低分子肝素。比较两组患者治疗后封闭抗体产生情况和妊娠结局与不良反应。结果:观察组封闭抗体转为阳性者40例,转阳率为88.9%(40/45);对照组封闭抗体转为阳性者31例,转阳率为88.6%(31/35)。两组患者封闭抗体转阳率的比较,差异无统计学意义(χ2=0.002,P=1.000)。观察组活产率明显高于对照组(95.6%vs 80.0%,χ2=4.771,P=0.037)。结论:URSA主动免疫治疗的基础上,联合应用低分子肝素,可进一步提高临床活产率。
[Abstract]:Objective: to observe the effect of low molecular weight heparin (LMWH) combined with active immunotherapy in the treatment of unexplained recurrent abortion. Methods: from January 2009 to December 2012, 80 patients with unexplained recurrent spontaneous abortion (unexplained recurrent spontaneous abortion,URSA) were divided into observation group (n = 45) and control group (n = 35) with informed consent. The patients in the control group were treated with active immunotherapy, combined with routine fetal preservation therapy after pregnancy, and the patients in the observation group were treated with low molecular weight heparin (LMWH) on the basis of the above treatment. The production of blocking antibody, pregnancy outcome and adverse reactions were compared between the two groups after treatment. Results: the positive conversion rate was 88.9% (40 / 45) in the observation group and 88.6% (31 / 35) in the control group, while the positive rate was 88.9% (40 / 45) in the observation group and 88.6% (31 / 35) in the control group. There was no significant difference in the positive conversion rate of blocking antibody between the two groups (蠂 2 = 0.002, P = 1.000). The living rate in the observation group was significantly higher than that in the control group (95.6%vs 80.0%, 蠂 2 = 4.771, P = 0.037). Conclusion: combined use of low molecular weight heparin (LMWH) on the basis of URSA active immunotherapy can further improve the clinical live rate.
【作者单位】：广州医科大学附属第二医院产科;
【分类号】：R714.21

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