福建省孕妇孕前BMI与胎儿先天性心脏病的关系
发布时间：2019-05-07 01:48
【摘要】：目的： 胎儿先天性心脏病（congenital heart disease，CHD），简称胎儿CHD，为我国出生缺陷首位病种，是婴儿死亡和致残的主要原因之一。CHD的病因十分复杂，本研究探讨孕妇孕前体重指数及其相关因素与胎儿CHD发病的关系，探寻CHD的高危影响因素，为预防CHD的发生及相关公共卫生干预措施的制定提供参考依据。 方法： 本研究采用以医院为基础的病例对照研究方法，收集福建省妇幼保健院（三级甲等医院）2010年1月至2014年1月期间符合纳入标准的孕妇，采用问卷调查的方法，共186例病例和286例对照纳入研究。根据孕妇孕前BMI大小，分为四组：体重过低组（BMI＜18.5），正常体重低值组（BMI=18.5～21.0），正常体重高值组（BMI=21.1～23.9）,体重超重组（BMI≥24.0）,采用SPSS19.0软件进行t检验、卡方检验、单因素方差分析、非条件单因素及多因素logistic回归分析。 结果： 1.孕前体重过低（BMI18.5）者，其胎儿CHD的风险增加（OR=2.062，95%CI:1.216-3.499），且更易患合并心外畸形的CHD （OR=6.000，95%CI:1.987-18.199）。正常体重低值者（BMI=18.5~21.0），其胎儿合并心外畸形的CHD风险增加（OR=4.186，95%CI:1.140-12.469）。 2.孕前BMI与胎儿CHD为何种临床解剖分型无明显相关。 3.多因素logistic分析：孕前体重过低者（BMI18.5），其胎儿患CHD风险增加（OR=2.190，95%CI：1.209-3.965）。对于怀孕头3个月的饮食习惯，仅食肉（OR=5.002，95%CI:1.345-18.604）或食肉多于蔬菜（OR=2.376，95%CI:1.007-5.605）均会增加CHD风险，补充复合维生素（OR=0.528，95%CI:0.342-0.815）和食用糖果巧克力（OR=0.475，95%CI:0.313-0.722）则降低胎儿CHD风险。居住于农村的孕妇，其胎儿患CHD风险较高（OR=3.336，95%CI；1.312-8.480）。具有高中水平（OR=0.198，95%CI：0.045-0.863）或大学及以上水平（OR=0.160，95%CI：0.038-0.681）等较高文化程度的孕妇，其胎儿患CHD风险较小。 结论： 1.孕妇孕前体重过低（BMI18.5），其胎儿发生CHD的可能性较大。 2.就怀孕头3个月的饮食习惯而言，仅食肉或食肉多于蔬菜均会增加胎儿CHD风险，补充复合维生素、食用糖果巧克力则降低胎儿CHD风险。 3.居住于农村的孕妇，，其胎儿患CHD风险较高，具有较高文化程度的孕妇，其胎儿患CHD风险较小。
[Abstract]:Objective: fetal congenital heart disease (congenital heart disease,CHD), referred to as fetal CHD, is the first type of birth defect in China and is one of the main causes of infant death and disability. The purpose of this study was to explore the relationship between pregnant women's body mass index (BMI) before pregnancy and the incidence of fetal CHD, to explore the high risk factors of CHD, and to provide reference for the prevention of CHD and the formulation of relevant public health intervention measures. Methods: a hospital-based case-control study was conducted to collect pregnant women who met the inclusion criteria from January 2010 to January 2014 in Fujian Maternal and Child Health Hospital (Grade 3A Hospital). A total of 186 cases and 286 controls were included in the study. According to the size of BMI before pregnancy, pregnant women were divided into four groups: underweight group (BMI < 18.5), normal low weight group (BMI=18.5~21.0), normal weight high value group (BMI=21.1~23.9), weight overweight group (BMI 鈮
本文编号：2470668
[Abstract]:Objective: fetal congenital heart disease (congenital heart disease,CHD), referred to as fetal CHD, is the first type of birth defect in China and is one of the main causes of infant death and disability. The purpose of this study was to explore the relationship between pregnant women's body mass index (BMI) before pregnancy and the incidence of fetal CHD, to explore the high risk factors of CHD, and to provide reference for the prevention of CHD and the formulation of relevant public health intervention measures. Methods: a hospital-based case-control study was conducted to collect pregnant women who met the inclusion criteria from January 2010 to January 2014 in Fujian Maternal and Child Health Hospital (Grade 3A Hospital). A total of 186 cases and 286 controls were included in the study. According to the size of BMI before pregnancy, pregnant women were divided into four groups: underweight group (BMI < 18.5), normal low weight group (BMI=18.5~21.0), normal weight high value group (BMI=21.1~23.9), weight overweight group (BMI 鈮
本文编号：2470668
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