IL-6在PROM孕妇中的表达及与破膜时间和宫内感染的关系

发布时间：2019-05-12 11:00

【摘要】：目的观察血清白细胞介素6(IL-6)在胎膜早破(PROM)孕妇中的表达,探讨其与破膜时间和宫内感染的关系。方法选取2014年1月-2016年12月于医院妇产科检查并住院分娩的200例孕妇为研究对象,其中PROM孕妇140例为实验组,足月未胎膜早破的正常分娩孕妇60例为对照组;实验组包括足月前胎膜早破(PPROM)孕妇70例和足月胎膜早破(TPROM)孕妇70例;比较两组患者临床指标。结果实验组血清WBC、CRP和IL-6表达均高于对照组(P0.05);实验组宫内感染率29.3%,高于对照组宫内感染率1.7%(P0.05);实验组中合并宫内感染者血清WBC、CRP和IL-6表达均高于无宫内感染者(P0.05);TPROM合并宫内感染者血清WBC和CRP表达高于无宫内感染者(P0.05);PPROM合并宫内感染者血清WBC、CRP和IL-6表达高于无宫内感染者(P0.05);与破膜时间24h的孕妇比较,宫内感染发生率、血清CRP和IL-6表达在破膜时间24h的孕妇明显增高(P0.05)。结论血清IL-6水平与PROM孕妇宫内感染、破膜时间长短密切相关。
[Abstract]:Objective to observe the expression of serum IL-6 (IL-6) in pregnant women with premature rupture of membranes (PROM) and to explore the relationship between IL-6 and rupture time and intrauterine infection. Methods from January 2014 to December 2016, 200 pregnant women who were examined and delivered in hospital from January 2014 to December 2016 were selected as the study subjects. Among them, 140 pregnant women with PROM were in the experimental group and 60 normal pregnant women with premature rupture of full-term membranes were in the control group. The experimental group included 70 pregnant women with premature rupture of (PPROM) and 70 pregnant women with premature rupture of (TPROM) before full term, and the clinical indexes of the two groups were compared. Results the expression of serum WBC,CRP and IL-6 in the experimental group was higher than that in the control group (P 0.05), and the intrauterine infection rate in the experimental group was 29.3%, which was higher than that in the control group (1.7%) (P 0.05). The expression of serum WBC,CRP and IL-6 in the experimental group was higher than that in the control group (P 0.05). The expression of serum WBC and CRP in the experimental group was higher than that in the control group (P 0.05). The expression of serum WBC,CRP and IL-6 in patients with PPROM complicated with intrauterine infection was higher than that in patients without intrauterine infection (P 0.05). Compared with the pregnant women with 24 h rupture time, the incidence of intrauterine infection and the expression of CRP and IL-6 in serum were significantly higher than those in the pregnant women with 24 h rupture time (P 0.05). Conclusion the level of serum IL-6 is closely related to uterine infection and rupture time of PROM pregnant women.
【作者单位】：义乌市中心医院产科;
【基金】：浙江省医学会临床科研资金项目(2011zyc-B07)
【分类号】：R711.32

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