小剂量阿司匹林对重度宫腔粘连术后子宫内膜容受性及妊娠结局的影响

发布时间：2019-05-23 13:40

【摘要】：目的:探讨小剂量阿司匹林对于重度宫腔粘连电切术后子宫内膜容受性的影响。方法:采用前瞻性随机单盲的方法,将我院宫腔镜下确诊为重度宫腔粘连并实施宫腔粘连电切术+宫腔球囊置入术后的125例患者随机分为研究组(A组)和对照组(B组),A组65例,术后给予补佳乐3 mg,3次/d+阿司匹林75 mg,1次/d,连续治疗1个月;B组60例,给予补佳乐3 mg,3次/d,连续治疗1个月。观察2组患者排卵日子宫内膜厚度、子宫内膜类型、子宫内膜容积、子宫动脉血流阻力指数(resistance index,RI),子宫动脉搏动指数(pulsed index,PI),术后l、3个月复查宫腔镜检查,随访妊娠结局。结果:(1)A组患者排卵日子宫内膜厚度较B组厚(P=0.000),A型内膜所占比例高于B组(P=0.004),差异具有显著性;RI,PI明显低于B组,差异具有显著性(P=0.000)。(2)2组患者子宫内膜容积差异无显著性(P=0.474)。(3)术后3个月A组宫腔形态恢复总有效率为60.0%(39/65),B组宫腔形态恢复总有效率为41.7%(25/60)(P=0.040),差异有统计学意义。(4)术后随访6~12个月,A组中35例试孕,已妊娠15例,B组21例试孕,已妊娠6例(P=0.033)。结论:重度宫腔粘连电切术后小剂量阿司匹林联合大剂量补佳乐口服可以明显改善其子宫内膜容受性,提高术后试孕患者妊娠率。
[Abstract]:Objective: to investigate the effect of low dose aspirin on intimal receptivity after resection of severe uterine adhesions. Methods: 125 patients with severe uterine adhesion diagnosed by hysteroscopy in our hospital were randomly divided into study group (group A) and control group (group B). Group A (n = 65) was treated with Bujiale 3 mg,3 / d aspirin 75 mg,1 / d for 1 month. Group B (n = 60) was treated with Bujiale 3 mg,3 / d for 1 month. The intimal thickness, intimal type, intimal volume, uterine artery blood flow resistance index (resistance index,RI) and uterine artery pulsatility index (pulsed index,PI) on ovulatory day were observed. Hysteroscopy was performed at 3 months after operation. Follow up the outcome of pregnancy. Results: (1) the intimal thickness of group A was thicker than that of group B (P 鈮，

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