短时IVF联合早期补救ICSI与half-ICSI预防初次助孕周期受精低下的比较

发布时间：2019-06-05 11:55

【摘要】：目的对比分析短时体外受精(IVF)或短时IVF联合早期补救卵胞浆内单精子显微注射(ICSI)与部分卵胞浆内单精子显微注射(half-ICSI)两种授精方式在首次助孕周期对预防IVF受精率低下的疗效。方法回顾性分析2015年5月1日—2016年12月31日初次助孕周期中因存在精卵结合障碍高危因素而接受短时IVF(或短时IVF联合联合早期补救ICSI)或half-ICSI预防IVF受精率低下患者的病例资料。根据授精方式分为短时IVF助孕组(A组,n=192)和half-ICSI助孕组(B组,n=85),比较两组患者的一般情况、受精情况、胚胎发育以及接受新鲜胚胎移植后的妊娠结局。为进一步分析受精情况,筛选A、B两组中IVF受精率低下周期(受精率≤30%)的患者,分别设为A1组(n=20)和B1组(n=9),比较A1、B1两组的卵子受精情况。结果与B组相比,A组不存在过度ICSI(0.0%vs89.8%,χ~2=479.888,P0.01)。A组正常受精率低于B组(73.3%vs 79.6%,χ~2=14.780,P0.01),但两组可用胚胎率、优质胚胎率、囊胚形成率以及接受新鲜胚胎移植后临床妊娠率、胚胎着床率、流产率差异均无统计学意义(P均0.05)。IVF受精率低下周期中,短时IVF联合早期补救ICSI可提高正常受精率(A1组77.9%,B1组49.4%,χ~2=28.833,P0.01)。结论相比half-ICSI,短时IVF联合早期补救ICSI可避免过度ICSI、提高IVF受精率低下周期的正常受精率,预防IVF受精率低下更加精确、有效。
[Abstract]:Objective to compare short-term in vitro fertilization (IVF) or short-term IVF combined with early remediation of intracytoplasmic sperm microinjection (ICSI) and partial intracytoplasmic sperm microinjection (half-ICSI) in the first trimester of pregnancy. The effect of stage on the prevention of low fertilizing rate of IVF. Methods from May 1, 2015 to December 31, 2016, short-term IVF (or short-term IVF combined with early remedial ICSI) or half-ICSI were used to prevent IVF fertilization due to the high risk factors of sperm-egg binding disorder in the first assisted pregnancy cycle. Case data of patients with low rate. According to the mode of indoctrination, the patients were divided into short-term IVF assisted pregnancy group (group A, n 鈮，

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