血清GnSAF水平与多囊卵巢综合征的相关性研究

发布时间：2019-06-15 06:17

【摘要】：目的：检测PCOS患者血清GnSAF水平及与PCOS各项指标间的关系，探讨其在PCOS发病的意义及其在临床上的应用。 方法：选取76名PCOS患者、67名对照者和7名卵巢功能衰退者，计算PCOS组和对照组体重指数（BMI）及腰臀比（WHR），测定各研究对象血清性激素水平（卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)）和GnSAF水平，行阴道超声下卵泡监测记录卵泡大小及数目，并对PCOS组患者行OGTT和Ins释放试验。应用SPSS21.0软件分析实验组和对照组血清GnSAF水平有无差异，使用Pearson相关系数分析GnSAF与其他指标间的相关性。 结果: （1）研究对象共150例，其中PCOS组76例，，对照组67例，卵巢功能衰退者7例。PCOS与对照组年龄、WHR比较，差异无统计学意义，具有可比性；两组BMI比较，差异有统计学意义。 （2）除FSH和E2外，PCOS组和对照组LH、T水平以及LH/FSH比值显著大于对照组（P0.01，P0.01，P0.01），两组间比较差异有统计学意义。 （3） PCOS组与对照组GnSAF水平分别为22.11±6.71pg/ml及20.11±5.92pg/ml，PCOS组高于对照组，但差异无统计学意义（P=0.062） （4） PCOS组GnSAF与FSH、E2呈负相关趋势，与LH、T呈正相关趋势，正常组GnSAF与各激素间呈负相关趋势，但无统计学意义。 （5） GnSAF浓度与卵泡数呈正相关趋势，与FSH呈负相关趋势，差异有统计学意义。 结论： （1）血清GnSAF水平与PCOS发病、卵泡发育障碍无相关性，需大样本进行进一步研究； （2）对预测卵巢储备功能有意义。
[Abstract]:Objective: to detect the level of serum GnSAF and its relationship with PCOS in patients with PCOS, and to explore its significance in the pathogenesis of PCOS and its clinical application. Methods: 76 patients with PCOS, 67 controls and 7 patients with ovarian dysfunction were selected to calculate the body mass index (BMI) and waist hip ratio (WHR),) of body mass index (BMI) and waist hip ratio (WHR),) in PCOS group and control group. The levels of serum sex hormone (E 2), testosterone (T) and GnSAF (E 2), testosterone (T) and GnSAF were measured by vaginal ultrasound. OGTT and Ins release tests were performed in PCOS group. The difference of serum GnSAF level between experimental group and control group was analyzed by SPSS21.0 software, and the correlation between GnSAF and other indexes was analyzed by Pearson correlation coefficient. Results: (1) there were 76 cases in PCOS group, 67 cases in control group and 7 cases in ovarian dysfunction. There was no significant difference in age and WHR between PCOS and control group, and there was significant difference between BMI group and control group. (2) except FSH and E2, the level of LH,T and the ratio of LH/FSH in PCOS group and control group were significantly higher than those in control group (P0.01, P01), and there was significant difference between the two groups. (3) the levels of GnSAF in PCOS group and control group were 22.11 卤6.71pg/ml and 20.11 卤5.92pg 鈮

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