不同剂量来曲唑促排卵效果及对内膜、性激素影响的研究

发布时间：2019-06-15 21:07

【摘要】：目的:比较3种不同剂量来曲唑(letrozol,LE)促排卵效果及对内膜、性激素的影响。方法:选择Ⅱ型排卵障碍的不孕患者92例,随机分为3组,第1组(30例)及第2组(32例)在月经第3天分别给予来曲唑2.5 mg/d、5 mg/d,共5 d,第3组(30例)在月经第3天顿服来曲唑20 mg。观察人绒毛膜促性腺激素(human chorionic gonadotropin,HCG)注射日的卵泡成熟天数、成熟卵泡数目、子宫内膜厚度、血雌二醇(estradiol,E2)、黄体生成素(luteinizing hormone,LH)、总睾酮(testosterone,T)水平、排卵率、未破卵泡黄素化综合征(luteinized unruptured follicle syndrome,LUFS)的发生率及排卵后7 d血E2、孕酮水平。结果:3组间HCG注射日的卵泡成熟天数、成熟卵泡数目、子宫内膜厚度、血E2、LH、T水平、排卵率以及排卵后7 d血孕酮水平差异均无统计学意义(P0.05)。3组间LUFS发生率、排卵后7 d血E2水平差异有统计学意义。结论:3组方案均能有效促进卵泡发育,HCG日内膜厚度均达到0.8 cm以上,排卵后血孕酮水平均高于60 nmol/L。仅LE 20 mg单次口服组排卵后7 d血E2水平可达自然生理周期黄体期正常水平,而总体给药剂量较低,使用方便,推荐可作为LE促排卵首选方案。
[Abstract]:Objective: to compare the effects of three different doses of letrozole (letrozol,LE) on ovulatory induction and intima and sex hormones. Methods: 92 infertile patients with type II ovulatory disorder were randomly divided into three groups. Group 1 (n = 30) and group 2 (n = 32) were given letrozole 2.5 mg/d,5 mg/d, for 5 days on the 3rd day of menstruation, and group 3 (n = 30) received letrozole 20 mg. on the 3rd day of menstruation. The days of follicular maturation, the number of mature follicles, the thickness of endometrium, the level of serum estridiol (estradiol,E2), luteinizing hormone (luteinizing hormone,LH), total testosterone (testosterone,T), ovulatory rate, the incidence of (luteinized unruptured follicle syndrome,LUFS) and the levels of E2 and progesterone 7 days after ovulatory were observed. Results: there were no significant differences in follicular maturation days, number of mature follicles, intimal thickness, blood E2, LH, T level, ovulatory rate and serum progesterone level 7 days after ovulatory among the three groups (P 0.05). There was significant difference in the incidence of LUFS among the three groups and the level of serum E2 7 days after ovulatory. Conclusion: all the three groups can effectively promote follicular development. The intimal thickness of HCG is above 0.8 cm, and the level of progesterone in blood after ovulatory is higher than 60 nmol/L.. Only LE 20 mg single oral group could reach the normal level of normal corpus phase 7 days after ovulatory, but the overall dose was low and easy to use. It is recommended that it can be used as the first choice for LE ovulatory induction.
【作者单位】：重庆市妇幼保健院生殖内分泌科;
【基金】：重庆市卫计委医学科研基金资助项目(编号:2010-2-323)
【分类号】：R714.8

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