HIFU消融率及消融效率与子宫肌瘤MRI信号表现的相关性研究
发布时间：2019-06-18 12:56
【摘要】：目的： 子宫肌瘤的MRI信号差异对其HIFU消融效果影响较大，本研究根据MRI T2WI信号及增强类型将肌瘤分为不同的组别，通过比较其消融率及单位体积所需辐照时间及能量的差异，探讨导致消融疗效及消融效率产生差异的可能性因素，同时为高强度聚焦超声(HIFU)消融治疗子宫肌瘤的消融率及消融效率进行预判，为临床适应症的选择提供理论基础。 方法： 选择经MRI确诊的症状性子宫肌瘤病例72例（72个肌瘤），并将其依据不同标准进行分组研究。依据T2WI信号强度差别分为低信号及等高信号肌瘤，病例数分别为41例及31例；依据T2WI信号均一性差别分为均匀信号及非均匀信号肌瘤，病例数分别为38例及34例；依据增强MRI T1WI强化程度分为轻度强化及明显强化肌瘤，病例数分别为38例及34例。然后对其分别进行HIFU消融治疗，治疗后次日行增强MRI评估肌瘤体积的消融范围，比较不同组别间消融率、单位体积辐照剂量及辐照时间的差异。 结果： 72例患者共72个子宫肌瘤接受了HIFU消融，T2低信号者消融率(88.85±9.32)％，T2等高信号者消融率(79.67±10.38)％，两者比较有统计学差异。T2均匀信号者消融率(83±10.98)％，T2非均匀信号者消融率(81±12.81)％，两者比较无统计学差异。T1轻度强化者消融率(86.40±8.94)％，T1明显强化者消融率(75.44±12.57)％，两者比较有统计学差异。同时，T1轻度强化者单位体积辐照剂量为(3.42±2.29)J/mm3，T1明显强化者单位体积辐照剂量为(6.85±5.14)J/mm3，两者比较有统计学差异。T1轻度强化者单位体积辐照时间为(8.33±5.73)S/cm3，，T1明显强化者单位体积辐照时间为(16.74±12.83)S/cm3，两者比较有统计学差异。 结论： T2WI低信号及T1WI轻度强化者易达到较高的消融率，是易于消融的标志；同时T1WI轻度强化者较强化明显者单位体积所需的能量、时间均更少，消融效率更高；再者MRI-T2WI联合动态增强MRI可用于预测HIFU消融子宫肌瘤的消融率及消融效率，指导临床方案的制定，值得进一步研究。
[Abstract]:Objective: the difference of MRI signal of uterine myoma has a great influence on the effect of HIFU ablation. According to the MRI T2WI signal and enhancement type, the myoma is divided into different groups. By comparing the ablation rate and the difference of irradiation time and energy per unit volume, the possible factors leading to the difference of ablation effect and ablation efficiency are discussed. At the same time, it can predict the ablation rate and ablation efficiency of high intensity focused ultrasound (HIFU) ablation in the treatment of uterine myoma, and provide a theoretical basis for the selection of clinical indications. Methods: 72 cases (72 myoma) of symptomatic uterine myoma diagnosed by MRI were selected and divided into two groups according to different criteria. According to the difference of T2WI signal intensity, the cases were divided into low signal myoma (41 cases) and iso-hyperintensity myoma (31 cases), uniform signal myoma (38 cases) and non-uniform signal myoma (34 cases) according to the uniformity of T2WI signal intensity. According to the enhancement degree of MRI T1WI, the cases were divided into mild enhancement and obvious enhancement, and the number of cases was 38 and 34, respectively. Then HIFU ablation was performed. The ablation range of myoma volume was evaluated by enhanced MRI the next day after treatment, and the ablation rate, irradiation dose per unit volume and irradiation time were compared among different groups. Results: 72 cases of uterine myoma underwent HIFU ablation. The ablation rate of T2 patients with low signal intensity was (88.85 卤9.32)%, and that of T2 patients with high signal intensity was (79.67 卤10.38)%. There was significant difference between the two groups. The ablation rate of T2 homogeneous signal group was (83 卤10.98)%, and that of T2 non-uniform signal group was (81 卤12.81)%. There was no significant difference between the two groups. The ablation rate of T2 patients with mild enhancement was (86.40 卤8.94)%. The ablation rate of T1 patients with obvious enhancement was (75.44 卤12.57)%, and there was significant difference between the two groups. At the same time, the unit volume irradiation dose per volume of T1 mild enhancement was (3.42 卤2.29) J 鈮
本文编号：2501506
[Abstract]:Objective: the difference of MRI signal of uterine myoma has a great influence on the effect of HIFU ablation. According to the MRI T2WI signal and enhancement type, the myoma is divided into different groups. By comparing the ablation rate and the difference of irradiation time and energy per unit volume, the possible factors leading to the difference of ablation effect and ablation efficiency are discussed. At the same time, it can predict the ablation rate and ablation efficiency of high intensity focused ultrasound (HIFU) ablation in the treatment of uterine myoma, and provide a theoretical basis for the selection of clinical indications. Methods: 72 cases (72 myoma) of symptomatic uterine myoma diagnosed by MRI were selected and divided into two groups according to different criteria. According to the difference of T2WI signal intensity, the cases were divided into low signal myoma (41 cases) and iso-hyperintensity myoma (31 cases), uniform signal myoma (38 cases) and non-uniform signal myoma (34 cases) according to the uniformity of T2WI signal intensity. According to the enhancement degree of MRI T1WI, the cases were divided into mild enhancement and obvious enhancement, and the number of cases was 38 and 34, respectively. Then HIFU ablation was performed. The ablation range of myoma volume was evaluated by enhanced MRI the next day after treatment, and the ablation rate, irradiation dose per unit volume and irradiation time were compared among different groups. Results: 72 cases of uterine myoma underwent HIFU ablation. The ablation rate of T2 patients with low signal intensity was (88.85 卤9.32)%, and that of T2 patients with high signal intensity was (79.67 卤10.38)%. There was significant difference between the two groups. The ablation rate of T2 homogeneous signal group was (83 卤10.98)%, and that of T2 non-uniform signal group was (81 卤12.81)%. There was no significant difference between the two groups. The ablation rate of T2 patients with mild enhancement was (86.40 卤8.94)%. The ablation rate of T1 patients with obvious enhancement was (75.44 卤12.57)%, and there was significant difference between the two groups. At the same time, the unit volume irradiation dose per volume of T1 mild enhancement was (3.42 卤2.29) J 鈮
本文编号：2501506
本文链接：https://www.wllwen.com/yixuelunwen/fuchankeerkelunwen/2501506.html
最近更新
教材专著
