子宫内膜息肉宫腔镜手术后孕激素的应用

发布时间：2019-06-22 09:35

【摘要】：目的:探讨子宫内膜息肉的宫腔镜手术治疗及术后应用孕激素预防复发的临床效果.方法:选取入院治疗的520例子宫内膜息肉患者做为研究对象,按照治疗方法的差异分为研究组258例与对照组262例,两组患者均给予子宫内膜息肉的宫腔镜手术治疗,研究组患者术后应用孕激素药物干预治疗,对照组患者术后无药物干预治疗.比较两组患者治疗前后组织雌激素受体(ER)、孕激素受体(PR)、血管内皮生长因子(VEGF)表达变化情况.术后6个月、1年随访,统计患者复发情况,子宫内膜厚度及血红蛋白指标.结果:研究组患者治疗后ER、PR及VEGF表达数显著少于对照组患者,研究组患者的复发率低于对照组患者,具统计学差异(P0.05).两组患者术后6个月子宫内膜厚度及血红蛋白指标变化接近,无统计学差异(P0.05);研究组患者术后1年子宫内膜厚度及血红蛋白指标变化显著优于对照组患者,具统计学差异(P0.05).结论:临床应用宫腔镜手术治疗子宫内膜息肉,效果确切,术后给予孕激素治疗可以有效预防术后复发,值得临床推广应用.
[Abstract]:Objective: to investigate the clinical effect of hysteroscopy in the treatment of endometrial polyps and the use of progesterone to prevent recurrence after operation. Methods: 520 patients with endometrial polyps were divided into study group (258 cases) and control group (262 cases) according to the difference of treatment methods. The patients in the two groups were treated with hysteroscopic surgery. The patients in the study group were treated with progesterone drugs after operation, while the patients in the control group were treated with no drug intervention after operation. The expression of estrogen receptor (ER), progesterone receptor (PR), vascular endothelial growth factor (VEGF) was compared between the two groups before and after treatment. Six months and one year after operation, the recurrence, intimal thickness and hemoglobin index were counted. Results: the expression of ER,PR and VEGF in the study group was significantly lower than that in the control group after treatment, and the recurrence rate in the study group was lower than that in the control group (P 0.05). There was no significant difference in intimal thickness and hemoglobin index between the two groups at 6 months after operation (P 0.05), but the changes of intimal thickness and hemoglobin index in the study group were significantly better than those in the control group one year after operation (P 0.05). Conclusion: hysteroscopic surgery is effective in the treatment of endometrial polyps. Postoperative progesterone therapy can effectively prevent postoperative recurrence and is worthy of clinical application.
【作者单位】：暨南大学附属第一医院妇产科;
【基金】：广东省科技厅科技计划项目(2007B06041054)
【分类号】：R713.4

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