多孔淀粉对卵巢切除大鼠脂质代谢的影响

发布时间：2019-06-29 11:57

【摘要】：目的:研究多孔淀粉对卵巢切除大鼠脂质代谢的影响。方法:将24只雌性SD大鼠按体质量随机分为3组,其中一组进行伪切除手术,其余两组进行双侧卵巢切除手术,手术后恢复1周,分别饲喂相应饲料。4周后,检测大鼠血脂、肝脂、粪便中中性固醇含量和胆汁酸含量以及肠道中典型微生物数量、短链脂肪酸浓度等指标。结果:多孔淀粉的替代添加可以显著降低大鼠血浆中甘油三酯(triglyceride,TG)、TG与高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)的比值(TG/HDL-C)、肝脏中总胆固醇(total cholesterol,TC)、TG和脂肪总质量,显著减少腹部脂肪堆积(P0.05);显著增加粪便中中性固醇和胆汁酸的排泄量(P0.05);同时促进肠道中益生菌增殖和短链脂肪酸浓度的提高。结论:多孔淀粉对雌激素缺乏引起的高脂血症具有较好的降脂、降胆固醇效果,对内源性脂质代谢紊乱具有较好的缓解作用。
[Abstract]:Objective: to study the effect of porous starch on lipid metabolism in ovariectomy rats. Methods: 24 female SD rats were randomly divided into three groups according to body mass. One group underwent pseudo-ovariectomy and the other two groups underwent bilateral ovariectomy. The rats were fed with corresponding diet for 1 week after operation. 4 weeks later, the blood lipid, liver fat, neutral sterol content and bile acid content in feces, the number of typical microorganisms in intestinal tract and the concentration of short chain fatty acids were measured. Results: the alternative addition of porous starch significantly decreased the ratio of triglyceride,TG), TG to high density lipoprotein cholesterol (TG/HDL-C) in plasma, total cholesterol (total cholesterol,TC), TG and fat) in liver, and decreased abdominal fat accumulation (P 0.05), and significantly increased the excretion of neutral sterol and bile acid in feces (P 0.05). At the same time, it promoted the proliferation of probiotics and the increase of short chain fatty acid concentration in intestinal tract. Conclusion: porous starch has a good effect on hyperlipidemia caused by estrogen deficiency, and has a good effect on relieving the disorder of endogenous lipid metabolism.
【作者单位】：西南大学食品科学学院;贵州省马铃薯研究所;
【分类号】：TS231;R713.6

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