腹腔镜手术联合米非司酮治疗子宫内膜异位症效果观察

发布时间：2019-07-05 21:49

【摘要】：目的观察腹腔镜手术联合米非司酮治疗子宫内膜异位症的疗效,以及对患者血清骨桥蛋白(OPN)、组织抑制因子1(TIMP-1)和基质金属蛋白酶9(MMP-9)水平的影响。方法将120例子宫内膜异位症患者随机分为A、B、C组各40例,均实施腹腔镜手术治疗;A、B组于术后第1次月经来潮第1天分别开始口服米非司酮25、10mg,1次/d,疗程3个月。治疗前后取静脉血检测血清OPN、TIMP-1和MMP-9,复查B超评价临床疗效及复发情况。结果各组治疗后血清OPN、TIMP-1和MMP-9水平低于治疗前(P均0.05),且A、B组治疗后各指标均低于C组(P均0.05),但A组和B组各指标比较无统计学意义(P均0.05);A组和B组治疗总有效率均高于C组而复发率低于C组(P均0.05),A组和B组治疗总有效率、复发率比较无统计学意义(P均0.05)。结论腹腔镜手术联合米非司酮治疗子宫内膜异位症可明显降低血清OPN、TIMP-1、MMP-9水平,提高患者疗效,且低剂量米非司酮即可取得较好效果。
[Abstract]:Objective to observe the efficacy of laparoscopic surgery combined with mifepristone in the treatment of Endometriosis and the effect of laparoscopic surgery combined with mifepristone on serum osteopontin (OPN), tissue inhibitor 1 (TIMP-1) and matrix metalloprotease 9 (MMP-9). Methods 120 patients with Endometriosis were randomly divided into A group (n = 40), group C (n = 40) and group B (n = 40). Group B was treated with mifepristone 25 mg, 10 mg, once a day for 3 months. Serum OPN,TIMP-1 and MMP-9, were taken before and after treatment to evaluate the clinical efficacy and recurrence. Results after treatment, the levels of serum OPN,TIMP-1 and MMP-9 in each group were lower than those before treatment, and the indexes in group B were lower than those in group C after treatment, but there was no significant difference between group A and group B. The total effective rate of group A and group B was higher than that of group C, but the recurrence rate was lower than that of group C (P < 0.05). There was no significant difference in the recurrence rate between group A and group B (P < 0.05). Conclusion Laparoscopic surgery combined with mifepristone can significantly reduce serum OPN,TIMP-1,MMP-9 level and improve the curative effect of patients with Endometriosis, and low dose mifepristone can achieve better results.
【作者单位】：东方市人民医院;海南省农垦三亚医院;
【基金】：海南省东方市科学研究院课题(DFKJXM201601)
【分类号】：R713.4

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