淫羊藿黄酮对药物卵巢去势引起的更年期综合征的临床疗效及安全性

发布时间：2019-07-06 14:30

【摘要】：目的探讨淫羊藿黄酮植物激素治疗药物卵巢去势引起的更年期综合征的临床疗效及安全性。方法 98例子宫内膜异位症患者随机分为对照组50例和试验组48例。2组患者于术后第1次月经来潮日皮下注射戈舍瑞林3.6 mg,28 d为1个周期,连续4个周期。21 d后,对照组口服维生素E 100 mg,每天1次,连续应用112 d;试验组给予淫羊藿黄酮10 mg·kg-1·d-1,连续应用112 d。观察2组患者治疗期间Kupperman绝经指数变化情况、子宫内膜厚度、血清雌二醇水平及不良反应发生情况。结果 2组患者治疗1个周期后Kupperman绝经指数均明显上升,对照组显著高于试验组(均P0.05)。对照组和试验组治疗前子宫内膜厚度为(3.21±0.55),(3.19±0.47)mm,治疗后为(3.11±0.49),(3.23±0.51)mm,差异无统计学意义(P0.05)。2组患者治疗前后血清雌二醇水平差异均无统计学意义(P0.05)。2组患者用药期间均无子宫内膜异位症复发,且无明显阴道出血及其他不良反应发生。结论淫羊藿黄酮植物激素可显著改善药物卵巢去势后引起的雌激素水平低下而出现的更年期症状,且无明显不良反应发生。
[Abstract]:Objective to investigate the clinical efficacy and safety of icariin flavonoids in the treatment of climacteric syndrome caused by ovariectomy. Methods 98 patients with Endometriosis were randomly divided into control group (n = 50) and experimental group (n = 48). The patients in the two groups were injected subcutaneously with 3. 6 mg,28 d for 4 cycles on the first menstrual day after operation. 21 days later, the control group was treated with vitamin E 100 mg, once a day for 112 days, and the experimental group was treated with icariin 10 mg kg- 1 路d-1 for 112 d. The changes of Kupperman menopausal index, intimal thickness, serum E2 level and adverse reactions were observed during treatment in the two groups. Results the menopausal index of Kupperman in the two groups increased significantly after one cycle of treatment, and the menopausal index in the control group was significantly higher than that in the experimental group (P 0.05). The intimal thickness of the control group and the experimental group was (3.21 卤0.55), (3.19 卤0.47) mm, after treatment (3.11 卤0.49), (3.23 卤0.51) mm, had no significant difference (P 0.05). There was no significant difference in serum E2 level between the two groups before and after treatment (P 0.05). There was no recurrence of Endometriosis in both groups. No obvious vaginal bleeding and other adverse reactions occurred. Conclusion the flavonoids of icariin can significantly improve the climacteric symptoms caused by low estrogen level after ovariectomy, and there are no obvious adverse reactions.
【作者单位】：暨南大学第二临床医学院深圳市人民医院妇科;
【基金】：广东省科技基金资助项目(A2009594)
【分类号】：R711.71

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