重组人干扰素α2b阴道泡腾胶囊结合射频消融术治疗宫颈糜烂合并HPV亚临床感染的临床观察

发布时间：2019-08-02 10:57

【摘要】：目的:探讨重组人干扰素α2b阴道泡腾胶囊结合射频消融术治疗宫颈糜烂合并人乳头瘤病毒(HPV)亚临床感染(SPI)的临床疗效及安全性。方法:选取2014年7月-2015年8月我院妇科门诊收治的宫颈糜烂合并SPI患者207例,按随机数字表法分为A、B、C组,各69例。A组患者于月经周期结束3 d后给予重组人干扰素α2b阴道泡腾胶囊80万IU,阴道后穹窿给药,qd,10 d为1个疗程,治疗3个疗程;B组患者进行射频消融术治疗;C组患者采用同等剂量重组人干扰素α2b阴道泡腾胶囊结合射频消融术治疗。所有患者随访半年。评价3组患者临床疗效及B、C组患者术后创面愈合率,术后2周临床症状消失率、并发症发生率,并记录不良反应。结果:B、C组患者宫颈糜烂治疗有效率分别为94.20%、98.55%,显著高于A组的62.32%;C组患者SPI有效率为92.75%,显著高于B组的69.57%和A组的53.62%;C组患者HPV感染有效率为86.96%,显著高于B组的63.77%,差异均有统计学意义(P0.05)。B组患者术后4、6、8周创面愈合率分别为10.14%、43.48%、97.10%,C组患者分别为52.17%、92.75%、100.00%;C组患者术后4、6周创面愈合率显著高于B组,差异有统计学意义(P0.05)。C组患者术后2周阴道出血和排液等临床症状消失率为81.16%,显著高于B组的43.48%,差异有统计学意义(P0.05)。B、C组患者并发症发生率分别为11.60%、4.35%,组间差异无统计学意义(P0.05)。两组患者均未见明显不良反应发生。结论:重组人干扰素α2b阴道泡腾胶囊结合射频消融术治疗宫颈糜烂合并SPI疗效较好,创面愈合时间短,且安全性较好。
[Abstract]:Objective: to investigate the clinical efficacy and safety of recombinant human interferon 伪 2b vaginal effervescent capsule combined with radiofrequency ablation in the treatment of cervical erosion complicated with subclinical infection of human papillomavirus (HPV). Methods: from July 2014 to August 2015, 20 patients with cervical erosion complicated with SPI were randomly divided into two groups: group A (n = 69) and group C (n = 69). After 3 days of menstrual cycle, patients in group A were given recombinant human interferon 伪 2b vaginal effervor capsule 800000 IU, posterior vaginal fornix, qd,10 d was a course of treatment for 3 courses, group B was treated with radiofrequency ablation, and group B was treated with radiofrequency ablation. Group C patients were treated with the same dose of recombinant human interferon 伪 2b vaginal effervescent capsule combined with radiofrequency ablation. All patients were followed up for half a year. To evaluate the clinical efficacy of the three groups and the wound healing rate of group C, the disappearance rate of clinical symptoms and the incidence of complications 2 weeks after operation, and to record the adverse reactions. Results: the effective rate of cervical erosion in group C was 94.20% and 98.55% respectively, which was significantly higher than that in group A (62.32%) and group C (92.75%), which was significantly higher than that in group B (6957%) and group A (53.62%). The effective rate of HPV infection in group C was 86.96%, which was significantly higher than that in group B (63.77%). The effective rate of HPV infection in group C was significantly higher than that in group B (P < 0.05). The wound healing rate in group C was 10.14%, 43.48% and 9710%, respectively, and that in group C was 52.17%, 92.75% and 100.00%, respectively. At 4 weeks after operation, the wound healing rate in group C was significantly higher than that in group B, the difference was statistically significant (P 0.05). The disappearance rate of vaginal bleeding and drainage in group). C was 81.16%, which was significantly higher than that in group B (43.48%) (P 0.05). The incidence of complications in group B and C was 11.60% and 4.35% respectively, and there was no significant difference between the two groups (P 0.05). No obvious adverse reactions were found in both groups. Conclusion: recombinant human interferon 伪 2b vaginal effervescent capsule combined with radiofrequency ablation is effective in the treatment of cervical erosion complicated with SPI, and the wound healing time is short and safe.
【作者单位】：承德医学院附属医院妇科;承德医学院基础医学院;
【基金】：承德市科学技术研究与发展计划项目(No.20122148,20142031)
【分类号】：R711.33;R737.33

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