Wnt信号通路成分Wnt-5a和β-连接蛋白在卵巢癌组织中的表达及意义

发布时间：2019-08-06 20:58

【摘要】：目的探讨Wnt信号通路成分Wnt-5a和β-连接蛋白(β-catenin)在卵巢癌发生、发展中的作用。方法应用免疫组织化学二步法检测60份卵巢癌组织中Wnt-5a和β-catenin表达;分析其表达与卵巢癌临床病理特征、预后的关系以及两者表达的相关性。结果 Wnt-5a在卵巢癌组织中阳性表达率为61.7%(37/60),其阳性表达与卵巢癌患者年龄、肿瘤大小、组织学类型、病理分级无明显相关性(P均0.05),与肿瘤转移相关(P0.05)。β-catenin在卵巢癌组织中阳性表达率为71.7%(43/60),其阳性表达与肿瘤的分期和转移相关(P均0.05)。Wnt-5a和β-catenin阳性表达患者生存时间明显低于阴性表达患者(P0.05)。Spearman法分析显示两者表达呈正相关(r=0.344,P=0.011)。在发生转移的患者中Wnt-5a与β-catenin共同阳性表达率高达70%(24/34)。结论 Wnt-5a和β-catenin通过非经典和经典Wnt通路在卵巢癌发展中发挥重要作用,两者高表达可能协同促进肿瘤转移,提示预后不良。
[Abstract]:Objective to investigate the role of Wnt signaling pathway components Wnt-5a and 尾-junction protein (尾-catenin) in the occurrence and development of ovarian cancer. Methods Immunohistochemical two-step method was used to detect the expression of Wnt-5a and 尾-catenin in 60 samples of ovarian cancer, and the relationship between the expression and clinicopathological features and prognosis of ovarian cancer and the correlation between them were analyzed. Results the positive expression rate of Wnt-5a in ovarian cancer tissues was 61.7% (37 鈮，

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