冻融胚胎移植单双胎妊娠早期血清催乳素的变化
发布时间：2019-08-15 15:54
【摘要】：目的探讨在经体外受精(in vitro fertilization,IVF)或单精子卵母细胞浆内注射(Intracytoplasmic sperm injection,ICSI)-胚胎移植冻融周期(Embryo freezing and thawing cycles,ET)(IVF/ICSI-ET)治疗的单胎及双胎早期妊娠中血清催乳素(prolactin,PRL)的变化趋势及差异,并评估其对先兆流产的预测价值。方法回顾性分析2015年8月至2016年2月在安徽医科大学第一附属医院生殖中心行IVF/ICSI-ET并获得妊娠的妇女281例,根据B超单双胎及有无阴道流血分为:单胎组163例(正常妊娠114例,先兆流产49例),双胎组118例(正常妊娠70例,先兆流产48例),检测各组妊娠前PRL值及妊娠6~9周时PRL值。结果各组在年龄、不孕类型、不孕年限、周期类型、基础血清催乳素等方面差异均无统计学意义(P0.05),妊娠后PRL值较基础PRL值明显升高,单胎组和双胎组早期妊娠PRL值差异有统计学意义(P0.05),但单胎正常组与先兆流产组、双胎正常组与先兆流产组之间催乳素值差异均无统计学意义(P0.05)。结论PRL值在早孕期明显上升,且在双胎妊娠中PRL值上升更显著,但对于判断先兆流产预后价值仍有待进一步研究。
[Abstract]:Objective to investigate the trend and difference of serum prolactin (prolactin,PRL) in early pregnancy treated with in vitro fertilized (in vitro fertilization,IVF) or intracytoplasmic injection of (Intracytoplasmic sperm injection,ICSI)-embryo transfer freeze-thaw cycle (Embryo freezing and thawing cycles,ET (IVF/ICSI-ET), and to evaluate its predictive value for threatened abortion. Methods from August 2015 to February 2016, 281 women who underwent IVF/ICSI-ET and obtained pregnancy in the Reproductive Center of the first affiliated Hospital of Anhui Medical University were divided into single pregnancy group (n = 163), twin group (n = 118), twin group (n = 70) and threatened abortion group (n = 48). The PRL values before pregnancy and at 6 / 9 weeks of pregnancy were measured. Results there was no significant difference in age, infertile type, infertile duration, cycle type and basic serum prolactin among the three groups (P 0.05). The PRL value after pregnancy was significantly higher than that in the basal PRL group. The PRL value of early pregnancy in the single fetus group and the twin group was significantly different (P 0.05), but there was no significant difference between the single fetus normal group and the threatened abortion group. There was no significant difference in prolactin between normal twin group and threatened abortion group (P 0.05). Conclusion PRL value increased significantly in early pregnancy, especially in twin pregnancy, but the prognostic value of threatened abortion still needs to be further studied.
【作者单位】： 安徽医科大学第一附属医院生殖中心;安徽省马鞍山市中心医院妇产科;安徽医科大学公共卫生学院;
【基金】：国家科技支撑计划(2012BAI32B00)
【分类号】：R714.8
本文编号：2527090
[Abstract]:Objective to investigate the trend and difference of serum prolactin (prolactin,PRL) in early pregnancy treated with in vitro fertilized (in vitro fertilization,IVF) or intracytoplasmic injection of (Intracytoplasmic sperm injection,ICSI)-embryo transfer freeze-thaw cycle (Embryo freezing and thawing cycles,ET (IVF/ICSI-ET), and to evaluate its predictive value for threatened abortion. Methods from August 2015 to February 2016, 281 women who underwent IVF/ICSI-ET and obtained pregnancy in the Reproductive Center of the first affiliated Hospital of Anhui Medical University were divided into single pregnancy group (n = 163), twin group (n = 118), twin group (n = 70) and threatened abortion group (n = 48). The PRL values before pregnancy and at 6 / 9 weeks of pregnancy were measured. Results there was no significant difference in age, infertile type, infertile duration, cycle type and basic serum prolactin among the three groups (P 0.05). The PRL value after pregnancy was significantly higher than that in the basal PRL group. The PRL value of early pregnancy in the single fetus group and the twin group was significantly different (P 0.05), but there was no significant difference between the single fetus normal group and the threatened abortion group. There was no significant difference in prolactin between normal twin group and threatened abortion group (P 0.05). Conclusion PRL value increased significantly in early pregnancy, especially in twin pregnancy, but the prognostic value of threatened abortion still needs to be further studied.
【作者单位】： 安徽医科大学第一附属医院生殖中心;安徽省马鞍山市中心医院妇产科;安徽医科大学公共卫生学院;
【基金】：国家科技支撑计划(2012BAI32B00)
【分类号】：R714.8
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