宫颈脱落细胞人乳头瘤病毒（HPV）E6/E7 mRNA检测在HPV阳性女性筛查中的应用（英文）
发布时间：2021-03-26 17:13
目的:基于临床样本探讨宫颈脱落细胞HPV E6/E7mR NA检测能否作为HPV阳性女性的筛查手段。创新点:首次比较了宫颈脱落细胞HPV E6/E7 mR NA检测与宫颈脱落细胞学检测对于HPV阳性女性宫颈活检结果的预测价值。方法:所有入组的HPV阳性女性均进行宫颈脱落细胞学及HPV E6/E7 mR NA检测。比较两种方法对于宫颈活检结果的预测价值。结论:对于HPV阳性的女性,高级别鳞状上皮内病变（HSIL）HPV E6/E7 mR NA阳性率高于低级别鳞状上皮内病变（LSIL）及正常病例。HPV E6/E7mR NA与细胞学检测相比,HSIL及以上级别病变的检测敏感性（89.52%vs.86.67%,P=0.671）、特异性（48.96%vs.48.96%,P=1.000）、阳性预测值（39.00%vs.38.24%,P=1.000）及阴性预测值（92.76%vs.90.97%,P=0.678）均无显著差异。HPV E6/E7 mR NA检测或能成为HPV阳性女性的一种新的筛查手段。
【文章来源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2017,18(03)SCICSCD
【文章页数】：7 页
【文章目录】：
1 Introduction
2 Materials and methods
2.1 Patient recruitment and sample collection
2.2 HPV testing
2.3 Cytology test
2.4 HPV E6/E7 m RNA detection
2.5 Colposcopy and histological diagnosis
2.6 Statistical analysis
3 Results
3.1 Histological and cytological diagnoses
3.2 Positive rate of HPV E6/E7 m RNA assay by histological diagnosis
3.3 Concordance between HPV E6/E7 m RNA assay and cytological test
3.4 Correlation of E6/E7 m RNA and cytology with histological diagnoses
4 Discussion
Compliance with ethics guidelines
本文编号：3101951
【文章来源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2017,18(03)SCICSCD
【文章页数】：7 页
【文章目录】：
1 Introduction
2 Materials and methods
2.1 Patient recruitment and sample collection
2.2 HPV testing
2.3 Cytology test
2.4 HPV E6/E7 m RNA detection
2.5 Colposcopy and histological diagnosis
2.6 Statistical analysis
3 Results
3.1 Histological and cytological diagnoses
3.2 Positive rate of HPV E6/E7 m RNA assay by histological diagnosis
3.3 Concordance between HPV E6/E7 m RNA assay and cytological test
3.4 Correlation of E6/E7 m RNA and cytology with histological diagnoses
4 Discussion
Compliance with ethics guidelines
本文编号：3101951
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