卵巢早衰患者血清雄激素水平的系统回顾和荟萃分析
发布时间:2021-04-25 08:32
第一部分:POF/POI患者血清雄激素水平的系统回顾和荟萃分析及与同期生育年龄妇女的比较目的:有关POF/POI患者血清雄激素(4个评估指标:睾酮、硫酸脱氢表雄酮、雄烯二酮和性激素结合球蛋白)水平的系统回顾和荟萃分析,将通过与同期生育年龄妇女的比较,明确POF/POI患者是否有较低的血清雄激素水平。方法:互联网系统检索PubMed、Cochrane Library和Medline数据库,根据纳入和排除标准筛选截止2018年2月的所有包含POF/POI患者雄激素水平检测的研究报告。在数据库总共2461个相关研究中,有关睾酮、硫酸脱氢表雄酮、雄烯二酮和性激素结合球蛋白评估指标,分别有14、8、10和9个研究报告最终纳入系统回顾和荟萃分析研究。分析(效应测量)方式采用随机效应模型,用标准误(standard mean deviation,SMD)与 95%置信区间(95%confidence interval,95%CI)表示。结果:与同期生育年龄妇女(n=937)比较,POF/POI患者(n=719)血清睾酮水平(均值,下同)明显下降,相应的SMD(95%CI)是-0.73[-0.99,-...
【文章来源】:浙江大学浙江省 211工程院校 985工程院校 教育部直属院校
【文章页数】:131 页
【学位级别】:硕士
【文章目录】:
致谢
序
中文摘要
ABSTRACT
ABBREVIATIONS
PART Ⅰ: A SYSTEMATIC REVIEW AND META-ANALYSIS ON SERUM ANDROGENPROFILES IN WOMEN WITH PREMATURE OVARIAN FAILURE VS FERTILE CONTROLS
1.1 BACKGROUND
1.2 METHODOLOGY
1.2.1 Eligibility Criteria
1.2.2 Search Strategy and Study Selection
1.2.3 Quality Assessment and Data Extraction
1.2.4 Statistical Analysis
1.3 MAIN STUDY CHARACTERISTICS
1.4 MEASUREMENT OF RISK BIAS
1.5 Results
1.6 DISCUSSION
1.7 CONCLUSION
PART Ⅱ: A SYSTEMATIC REVIEW AND META-ANALYSIS ON SERUM ANDROGENPROFILES IN WOMEN WITH PREMATURE OVARIAN FAILURE VS POSTMENOPAUSALCONTROLS
2.1 BACKGROUND
2.2 METHODOLOGY
2.2.1 Eligibility Criteria
2.2.2 Search Strategy and Study Selection:
2.2.3 Quality Assessment and Data Extraction:
2.2.4 Statistical Analysis
2.3 MAIN STUDY CHARACTERISTICS
2.4 RESULTS
2.5 DISCUSSION
2.6 CONCLUSION
REFERENCES
文献综述(REVIEW)
References
作者简历
本文编号:3159065
【文章来源】:浙江大学浙江省 211工程院校 985工程院校 教育部直属院校
【文章页数】:131 页
【学位级别】:硕士
【文章目录】:
致谢
序
中文摘要
ABSTRACT
ABBREVIATIONS
PART Ⅰ: A SYSTEMATIC REVIEW AND META-ANALYSIS ON SERUM ANDROGENPROFILES IN WOMEN WITH PREMATURE OVARIAN FAILURE VS FERTILE CONTROLS
1.1 BACKGROUND
1.2 METHODOLOGY
1.2.1 Eligibility Criteria
1.2.2 Search Strategy and Study Selection
1.2.3 Quality Assessment and Data Extraction
1.2.4 Statistical Analysis
1.3 MAIN STUDY CHARACTERISTICS
1.4 MEASUREMENT OF RISK BIAS
1.5 Results
1.6 DISCUSSION
1.7 CONCLUSION
PART Ⅱ: A SYSTEMATIC REVIEW AND META-ANALYSIS ON SERUM ANDROGENPROFILES IN WOMEN WITH PREMATURE OVARIAN FAILURE VS POSTMENOPAUSALCONTROLS
2.1 BACKGROUND
2.2 METHODOLOGY
2.2.1 Eligibility Criteria
2.2.2 Search Strategy and Study Selection:
2.2.3 Quality Assessment and Data Extraction:
2.2.4 Statistical Analysis
2.3 MAIN STUDY CHARACTERISTICS
2.4 RESULTS
2.5 DISCUSSION
2.6 CONCLUSION
REFERENCES
文献综述(REVIEW)
References
作者简历
本文编号:3159065
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